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ProteomicsProject title: Effect of FHD-286 or BRG1/BRM degrader AU15330 on protein expressions in MLL1-rearranged AML cells
MOLM13 cells and patient-derived de novo AML cells with MLL1 rearrangement were treated with 100 nM of FHD-286 or 100 nM of AU15330, a dual BRG1/BRM protein degrader for 48 hours. The goal was to determine the global protein expression alterations that correlate with the cell cycle, growth inhibitor...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD055994 | Pride
Fhd-286 Au15330 Protac Chromatin 
GenomicsTargeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer (ATAC-Seq)
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer (ATAC-Seq)
PRJNA1073577 | ENA
GenomicsIRF4 requires ARID1A to establish plasma cell identity in multiple myeloma (RNA-Seq human 16).
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma (RNA-Seq human 16).
PRJNA1066811 | ENA
GenomicsIRF4 requires ARID1A to establish plasma cell identity in multiple myeloma (CUT&RUN human 8).
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma (CUT&RUN human 8).
PRJNA1066813 | ENA
GenomicsTargeting SWI/SNF ATPases in H3.3K27M Diffuse Intrinsic Pontine Gliomas [ATAC-Seq]
Targeting SWI/SNF ATPases in H3.3K27M Diffuse Intrinsic Pontine Gliomas [ATAC-Seq]
PRJNA954669 | ENA
GenomicsIRF4 requires ARID1A to establish plasma cell identity in multiple myeloma (ATAC-Seq human 8)
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma (ATAC-Seq human 8)
PRJNA1066809 | ENA
GenomicsTargeting SWI/SNF ATPases in H3.3K27M Diffuse Intrinsic Pontine Gliomas [RNA-Seq]
Targeting SWI/SNF ATPases in H3.3K27M Diffuse Intrinsic Pontine Gliomas [RNA-Seq]
PRJNA954670 | ENA
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