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GenomicsModulation of Aub–Tdrd interactions elucidates piRNA amplification and germ plasm formation
Modulation of Aub–Tdrd interactions elucidates piRNA amplification and germ plasm formation
PRJNA655907 | ENA
GenomicsModulation of Aub–Tdrd interactions elucidates piRNA amplification and germ plasm formation
Aub protein guided by piRNAs ensures genome integrity by cleaving retrotransposons and genome propagation by trapping mRNAs to form the germ plasm that instructs germ cell formation. The amino terminus of Aub (Aub-NT) is rich in arginines (Aub-NTRs), which are symmetrically dimethylated (sDMAs), and...
ORGANISM(S): Drosophila melanogaster 
2020-12-14 | GSE155874 | GEO
TranscriptomicsVreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.
Here, we analyzed small RNA libraries derived from ovarian tissues heterozygous or mutant for the Tudor gene, Vreteno. In the absence of vret, Piwi-bound piRNAs are lost without changes in piRNA precursor transcript production, supporting a role for Vret in primary piRNA biogenesis. In the germline,...
ORGANISM(S): Drosophila melanogaster 
2011-08-15 | E-GEOD-30088 | biostudies-arrayexpress
UnknownModulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation.
Not available
S-EPMC7772777 | biostudies-literature
ProteomicsAubergine protein interactors in 0-2 hour-Drosophila embryos
To identify Aub function in mRNA regulation in the Drosophila embryo, we have performed mass spectrometry analysis of Aub interactors, following immunoprecipitation of GFP-Aub in 0-2 hour-embryos. Immunoprecipitation of GFP alone was used as negative control. Because Aub accumulates at high levels i...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-04-27 | PXD016399 | Pride
Aub  piwi protein  translation  drosophila  embryos 
TranscriptomicsFLX sequencing of Piwi-associated small RNAs extracted from Drosophila ovarian somatic cells (OSC)
piRNAs function in silencing retrotransposons by associating with the PIWI proteins, AGO3, Aub, and Piwi, in Drosophila germlines. Bioinformatics analyses of piRNAs in Drosophila ovaries suggested that piRNAs are produced by two systems, the primary processing pathway and the amplification loop, fro...
ORGANISM(S): Drosophila melanogaster 
2009-10-01 | E-GEOD-15137 | biostudies-arrayexpress
UnknownLabel-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E.
Not available
S-EPMC7923474 | biostudies-literature
TranscriptomicsTranscriptomic analysis of wild-type, spn-E and aub mutant 0-2h- and 2-4h-embryos
We used microarrays to identify unstable mRNAs in wild-type embryos by comparing the transcriptomes derived from 0-2h- and 2-4h-embryos. We then analyzed which of these unstable mRNAs are stabilized in embryos from aub or spn-E mutant mothers (aub or spn-E mutant embryos) by comparing mutant and wil...
ORGANISM(S): Drosophila melanogaster 
2015-08-19 | GSE70775 | GEO
UnknownBeyond the numbers-understanding women's experiences of accessing care for abnormal uterine bleeding (AUB): a qualitative study.
Not available
S-EPMC7674079 | biostudies-literature
TranscriptomicsVreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila
In Drosophila, Piwi proteins associate with Piwi-interacting RNAs (piRNAs) and protect the germline genome by silencing mobile genetic elements. This defense system acts in germline and gonadal somatic tissue to preserve germline development. Genetic control for these silencing pathways varies great...
ORGANISM(S): Drosophila melanogaster 
2011-09-28 | E-GEOD-30360 | biostudies-arrayexpress
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