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ProteomicsComputational prediction combined with proteogenomics unveils widespread non-AUG translation initiation events in plants
Non-AUG translation initiation is crucial for regulating translation, which can generate N-terminally extended protein isoforms with diverse biological functions. However, a comprehensive view of non-AUG translation initiation events with N-terminal extensions (NTEs) across monocots and dicots remai...
ORGANISM(S): Glycine max Zea mays (Maize) Oryza sativa (Rice) 
2026-04-27 | PXD058528 | Pride
Non-aug translation initiation  n-terminally extended protein isoforms  n-terminal extensions (ntes)  upstream translation initiation sites (utiss)  proteogenomics  monocots and dicots 
ProteomicsMultiple cis acting polypyrimidine tract elements regulate a cooperative mechanism for Triticum mosaic virus internal ribosomal entry site activity=]
Diverse elements within the 5’ untranslated region of an mRNA can influence the translation efficiency at the main AUG codon. We previously identified a core picornaviral like Y16X11-AUG motif with 16-nt polypyrimidine CU-tract separated by an 11-nt spacer sequence from the 13th AUG codon recognized...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-05-04 | PXD031443 | Pride
Yx-aug Aug selection Ribosomal subunit Ires Triticum mosaic virus Translation initiation Polypyrimidine-tract 
UnknownYeast 18 S rRNA is directly involved in the ribosomal response to stringent AUG selection during translation initiation.
Not available
S-EPMC2952221 | biostudies-literature
UnknownThousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals.
Not available
S-EPMC9789052 | biostudies-literature
OtherEvolutionarily Conserved Inhibitory uORFs Sensitize Hox mRNA Translation to Start Codon Selection Stringency
Translation start site selection in eukaryotes is influenced by context nucleotides flanking the AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a search of human genes, we identified 5 Hox gene paralogs initiated by AUG codons in conserved suboptimal conte...
ORGANISM(S): Mus musculus 
2022-02-21 | GSE184515 | GEO
OtherBi-directional ribosome scanning controls the stringency of start codon selection
The fidelity of start codon recognition by ribosomes is paramount during protein synthesis. The textbook knowledge of eukaryotic translation initiation depicts 5’→3’ unidirectional migration of the pre-initiation complex (PIC) along the 5’UTR. In probing translation initiation from ultra-short 5’UTR...
ORGANISM(S): Homo sapiens Mus musculus 
2021-11-24 | GSE176058 | GEO
UnknownMutations in Caenorhabditis elegans eIF2beta permit translation initiation from non-AUG start codons.
Not available
S-EPMC2870950 | biostudies-literature
UnknownCGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins.
Not available
S-EPMC4854189 | biostudies-literature
UnknownThe eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.
Not available
S-EPMC1276705 | biostudies-literature
UnknownThe indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection.
Not available
S-EPMC2824034 | biostudies-literature
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