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TranscriptomicsPolypyrimidine tract-binding protein homologues from Arabidopsis are key regulators of alternative splicing with implications in fundamental developmental processes
Alternative splicing (AS) generates transcript variants by the definition of different exonic and intronic regions and causes a massive expansion of transcriptome diversity. Changes in AS patterns have been found to be linked to manifold biological processes, yet fundamental aspects such as the regu...
ORGANISM(S): Arabidopsis thaliana 
2012-10-22 | E-GEOD-41433 | biostudies-arrayexpress
TranscriptomicsDrosophila PTB regulates dorso-ventral patterning genes in embryos
Drosophila PTB (Polypyrimidine Tract-binding protein dmPTB) regulates dorso-ventral patterning genes in embryos Comparison of wild type (yw genotype) and PTB mutant (heph03429) drosophila embryos
ORGANISM(S): Drosophila melanogaster 
2014-05-10 | E-GEOD-57517 | biostudies-arrayexpress
ProteomicsMultiple cis acting polypyrimidine tract elements regulate a cooperative mechanism for Triticum mosaic virus internal ribosomal entry site activity=]
Diverse elements within the 5’ untranslated region of an mRNA can influence the translation efficiency at the main AUG codon. We previously identified a core picornaviral like Y16X11-AUG motif with 16-nt polypyrimidine CU-tract separated by an 11-nt spacer sequence from the 13th AUG codon recognized...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-05-04 | PXD031443 | Pride
Yx-aug Aug selection Ribosomal subunit Ires Triticum mosaic virus Translation initiation Polypyrimidine-tract 
ProteomicsPolypyrimidine Tract Binding Proteins PTBP1 and PTBP2 Interact with Distinct Proteins Under Splicing Conditions
RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, PTBP1 and PTBP2, are paralogous RNA binding proteins that play a critical role in the process of neuronal differentiation and maturatio...
ORGANISM(S): Homo sapiens (Human) 
2022-01-20 | PXD029899 | Pride
Nptb Ptbp1 Ptbp2 Splicing Ptbp Ptb Lc-ms/ms 
GenomicsPolypyrimidine tract binding proteins are essential for B cell development
Polypyrimidine tract binding proteins are essential for B cell development
PRJNA563911 | ENA
GenomicsPolypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
PRJNA787360 | ENA
UnknownExon repression by polypyrimidine tract binding protein.
Not available
S-EPMC1370756 | biostudies-literature
UnknownThe domains of polypyrimidine tract binding protein have distinct RNA structural preferences.
Not available
S-EPMC2766422 | biostudies-literature
TranscriptomicsGene Expression and Exon Splicing Change Analysis of Mouse N2A Cell Transcriptome upon Polypyrimidine tract-binding protein depletion.
Purpose : Splicing factors regulate splice site choices in pre-mRNA and determine final exon set in mRNA. To understand mechanisms of splicing regulation, it is important to identify and characterize exon targets of splicing factors. Recently, development of RNA-seq technology enables researchers to...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-45119 | biostudies-arrayexpress
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
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