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ProteomicsPolypyrimidine Tract Binding Proteins PTBP1 and PTBP2 Interact with Distinct Proteins Under Splicing Conditions
RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, PTBP1 and PTBP2, are paralogous RNA binding proteins that play a critical role in the process of neuronal differentiation and maturatio...
ORGANISM(S): Homo sapiens (Human) 
2022-01-20 | PXD029899 | Pride
Nptb Ptbp1 Ptbp2 Splicing Ptbp Ptb Lc-ms/ms 
ProteomicsRAVER1 interconnects lethal EMT and miR/RISC activity by the control of alternative splicing
The RAVER1 protein was proposed to serve as a co-factor in guiding the PTBP-dependent control of alternative splicing (AS). Whether RAVER1 solely acts in concert with PTBPs and how it affects cancer cell fate remained elusive. Here we provide the first comprehensive investigation of RAVER1-contro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-11 | PXD043342 | Pride
Cancer Emt Raver1 Tgfb Microrna Ptbp Alternative splicing Risc 
OtherSplicing analyses of 46C mESCs following PTBP depletion
PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentia...
ORGANISM(S): Mus musculus 
2016-01-01 | GSE71075 | GEO
OtherSplicing analyses of 46C mNPCs following PTBP depletion
PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentia...
ORGANISM(S): Mus musculus 
2016-01-01 | GSE70985 | GEO
UnknownSelection and validation of reference genes for qRT-PCR analysis during fruit ripening of red pitaya (Hylocereus polyrhizus).
Not available
S-EPMC8564333 | biostudies-literature
GenomicsMus musculus
Splicing analyses of 46C mNPCs following PTBP depletion
PRJNA290074 | ENA
GenomicsMus musculus
Splicing analyses of 46C mESCs following PTBP depletion
PRJNA290312 | ENA
UnknownPTBPs: An immunomodulatory-related prognostic biomarker in pan-cancer
Not available
S-EPMC9531344 | biostudies-literature
UnknownHuman umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia/ischemia in rats.
Not available
S-EPMC9120712 | biostudies-literature
UnknownThe pediatric template of brain perfusion.
Not available
S-EPMC4413243 | biostudies-literature
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