Sort   by:  
 Page size 
ProteomicsPolypyrimidine Tract Binding Proteins PTBP1 and PTBP2 Interact with Distinct Proteins Under Splicing Conditions
RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, PTBP1 and PTBP2, are paralogous RNA binding proteins that play a critical role in the process of neuronal differentiation and maturatio...
ORGANISM(S): Homo sapiens (Human) 
2022-01-20 | PXD029899 | Pride
Nptb Ptbp1 Ptbp2 Splicing Ptbp Ptb Lc-ms/ms 
TranscriptomicsWild type vs. Ptbp2 KO mouse embryonic cortex RNA
To assess the requirement of Ptbp2 for alternative processing of RNA in mouse brain RNA from the cortex of 3 wild type and 3 Ptbp2 KO E18.5 mice. One array per biological replicate. Comparative analysis
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47566 | biostudies-arrayexpress
TranscriptomicsWild type vs. Ptbp2 KO mouse E18.5 cortex RNA
To assess the requirement of Ptbp2 for alternative mRNA expression in mouse brain RNA from the cortex of 4 wild type and 4 Ptbp2 KO E18.5 mice. One array per sample (biological replicate), 8 arrays total.
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47565 | biostudies-arrayexpress
TranscriptomicsPtbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain [HITS-CLIP]
Two polypyrimidine tract RNA-binding proteins (PTBs), one near-ubiquitously expressed (Ptbp1) and another highly tissue-restricted (Ptbp2), regulate RNA in interrelated but incompletely understood ways. Ptbp1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by P...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47564 | biostudies-arrayexpress
ProteomicsPTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in nuclear neuronal extract.
PTBP1 and PTBP2 are highly conserved paralogs, yet exhibit distinct splicing patterns. Here we use mass spectrometry to show that PTBP1 and PTBP2 interact with distinct proteins and undergo distinct post translational modifications under splicing conditions in neuronal nuclear extract.
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD058740 | Pride
Post-translational modificantions Ptbp1 Mass spectrometry Splicing Ptbp2 Protein-protein interactions 
TranscriptomicsMicroarray analysis of alternative splicing in PTBP2 knockout mouse brain
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. The splicing regulatory proteins PTBP1 and PTBP2 show distinct temporal expression profiles in the developing brain. Neuronal progenitor cells predominantly express PTBP1, whereas developing neuro...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-51738 | biostudies-arrayexpress
ProteomicsPtbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr
The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and branching. While its functions in alternative splicin...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-13 | PXD035196 | Pride
Neuron Hnrnpr Axon Ptbp2 Interactome 
GenomicsPTBP2 knock-down RNA-seq from human iPSC-neurons
PTBP2 knock-down RNA-seq from human iPSC-neurons
PRJNA851735 | ENA
GenomicsHuman Clariom D Transcriptome profiling of microRNA-mediated neuronal reprogramming with PTBP2 knockdown
Human Clariom D Transcriptome profiling of microRNA-mediated neuronal reprogramming with PTBP2 knockdown
PRJNA494968 | ENA
GenomicsAxonogenesis is coordinated by alternative splicing programming and splicing regulator PTBP2
Axonogenesis is coordinated by alternative splicing programming and splicing regulator PTBP2
PRJNA512484 | ENA
Sort   by:  
 Page size