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TranscriptomicsPTB CLIP-seq
Recent transcriptome analysis indicates that >90% of human genes undergoes alternative splicing, underscoring the contribution of differential RNA processing to diverse proteomes in higher eukaryotic cells. The polypyrimidine tract binding protein PTB is a well-characterized splicing repressor, but ...
ORGANISM(S): Homo sapiens 
2009-12-24 | E-GEOD-19323 | biostudies-arrayexpress
GenomicsEnterobacter sp. PTB
Enterobacter sp. PTB Genome sequencing
PRJNA1106631 | ENA
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates [siRNA data]
This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative spl...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40961 | biostudies-arrayexpress
TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Sh...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-41718 | biostudies-arrayexpress
ProteomicsIdentification of PTB ΔNLS-GFP interacting proteins precipitated by magnetic beads against GFP
The purpose of the study was to determine proteins that specially interact cytoplasmic PTB. PTB is an RNA binding protein that shuttles between the nucleus and cytoplasm. To identified proteins interacting with cytoplasmic PTB, nucleus localization signal was deleted (PTB ΔNLS-GFP) and overexpresse...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026837 | Pride
Ptb 
TranscriptomicsMADS: a New and Improved Method for Analysis of Differential Alternative Splicing by Exon-tiling Microarrays
We describe a method, MADS (Microarray Analysis of Differential Splicing), for discovery of differential alternative splicing from exon tiling microarrays. MADS incorporates a series of low-level analysis algorithms motivated by the “probe-rich” design of exon arrays, including background correction...
ORGANISM(S): Mus musculus 
2008-05-09 | E-GEOD-11344 | biostudies-arrayexpress
TranscriptomicsDrosophila PTB regulates dorso-ventral patterning genes in embryos
Drosophila PTB (Polypyrimidine Tract-binding protein dmPTB) regulates dorso-ventral patterning genes in embryos Comparison of wild type (yw genotype) and PTB mutant (heph03429) drosophila embryos
ORGANISM(S): Drosophila melanogaster 
2014-05-10 | E-GEOD-57517 | biostudies-arrayexpress
TranscriptomicsDirect Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell lineage-specific transcription factors. Here we report that repression of a single RNA binding protein PTB, which occurs during normal brain development via the action of miR-124, is s...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-42701 | biostudies-arrayexpress
TranscriptomicsCLIP-Seq of H. sapiens HeLa cells to investigate transcriptome-wide mapping of PTB / hnRNP I
PTB iCLIP-seq in HeLa cells
ORGANISM(S): Homo sapiens 
2014-12-01 | E-MTAB-3108 | biostudies-arrayexpress
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates [differentiation data]
This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative spl...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40956 | biostudies-arrayexpress
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