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Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR
The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and branching. While its functions in alternative splicin...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-13 | PXD035196 | Pride
RNA binding proteins (RBPs) interact with and tightly regulate the fate of messenger RNAs but how RNA targets are recognized remains a challenging question. RBPs often contain multiple domains known to directly bind RNA, such as RNA recognition motifs (RRMs), as well as domains whose RNA binding cap...
ORGANISM(S): synthetic construct 
2026-08-31 | GSE296428 | GEO
Papillary thyroid carcinoma (PTC) is the most prevalent endocrine malignancy, and aggressive PTC phenotypes contribute to poor patient prognosis. Circular RNAs (circRNAs) are stable non-coding RNAs critically involved in tumor progression, yet their regulatory mechanisms in PTC remain largely unclea...
ORGANISM(S): Homo sapiens 
2026-08-21 | GSE343826 | GEO
CircATP5C1 drives papillary thyroid carcinoma progression through HNRNPR nuclear export and BCL2L1 upregulation in a ubiquitination‑dependent manner
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