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ProteomicsRAVER1 interconnects lethal EMT and miR/RISC activity by the control of alternative splicing
The RAVER1 protein was proposed to serve as a co-factor in guiding the PTBP-dependent control of alternative splicing (AS). Whether RAVER1 solely acts in concert with PTBPs and how it affects cancer cell fate remained elusive. Here we provide the first comprehensive investigation of RAVER1-contro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-11 | PXD043342 | Pride
Cancer Emt Raver1 Tgfb Microrna Ptbp Alternative splicing Risc 
GenomicsRAVER1 interconnects TGFB signaling, EMT and miR/RISC activity by modulating alternative splicing [A549_RAVER1_KD]
RAVER1 interconnects TGFB signaling, EMT and miR/RISC activity by modulating alternative splicing [A549_RAVER1_KD]
PRJNA973631 | ENA
GenomicsRAVER1 interconnects TGFB signaling, EMT and miR/RISC activity by modulating alternative splicing [A549_RAVER1_KO]
RAVER1 interconnects TGFB signaling, EMT and miR/RISC activity by modulating alternative splicing [A549_RAVER1_KO]
PRJNA973630 | ENA
UnknownApo raver1 structure reveals distinct RRM domain orientations.
Not available
S-EPMC3189531 | biostudies-literature
UnknownThe PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.
Not available
S-EPMC291850 | biostudies-literature
GenomicsRaver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
PRJNA1182361 | ENA
UnknownThe metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA.
Not available
S-EPMC3835166 | biostudies-literature
UnknownRaver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.
Not available
S-EPMC2150882 | biostudies-literature
UnknownCrystallographic analysis of polypyrimidine tract-binding protein-Raver1 interactions involved in regulation of alternative splicing.
Not available
S-EPMC3420021 | biostudies-literature
TranscriptomicsRaver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
Multiple cell death and inflammatory signaling pathways converge on two critical factors: receptor interacting serine/threonine kinase 1 (RIPK1) and caspase-8. Careful regulation of these molecules is critical to control apoptosis, pyroptosis and inflammation. Here we discovered a pivotal role of Ra...
ORGANISM(S): Mus musculus 
2025-03-05 | GSE281137 | GEO
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