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TranscriptomicsSlicing-Independent RISC Activation Requires the Argonaute PAZ Domain
Small RNAs regulate the genetic networks through a ribonucleoprotein complex called the RNA induced silencing complexes (RISC), which in mammals contains at its center one of four Argonaute proteins (Ago1-4). A key regulatory event in the RNAi and miRNA pathways is Ago loading, where double stranded...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39146 | biostudies-arrayexpress
TranscriptomicsDifferential RISC association of endogenous human microRNAs predicts their inhibitory potential
It has previously been assumed that the generally high stability of microRNAs (miRNAs) reflects their tight association with Argonaute (Ago) proteins, essential components of the RNA-induced silencing complex (RISC). However, recent data have suggested that the majority of mature miRNAs are not, in ...
ORGANISM(S): Homo sapiens 
2014-05-30 | E-GEOD-58127 | biostudies-arrayexpress
TranscriptomicsThe mRNA and microRNA expression profile of the RNA-induced silencing complex in human U-87 astrocytoma cells and primary human astrocytes
mRNA and microRNA expression was examined in global cellular fractions and in RNA-induced silencing complex (RISC)-immunoprecipitated cell fractions in cultured primary human astrocytes (ScienCell) and in cultured human U-87 MG astrocytoma cells (ATCC). ABSTRACT: Background: GW/P bodies are cytoplas...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-21514 | biostudies-arrayexpress
TranscriptomicsNovel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns [RISC trap immunoprecipitation]
Major non primate-primate differences in corticogenesis include the dimensions, precursor lineages and developmental timing of the germinal zones (GZ). microRNAs (miRNAs) of laser dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP a...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-52607 | biostudies-arrayexpress
TranscriptomicsmRNA- and RISC-sequencing of mouse hearts overexpressing miR-133a
miR-133a-3p is a highly abundant cardiomyocyte-enriched microRNA whose expression is persistently decreased in response to pressure overload (or transverse aortic constriction, TAC) in mice. Overexpression of miR-133a in cardiomyocytes of mouse hearts in vivo (under the control of the Myh6 promoter)...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-65141 | biostudies-arrayexpress
ProteomicsRAVER1 interconnects lethal EMT and miR/RISC activity by the control of alternative splicing
The RAVER1 protein was proposed to serve as a co-factor in guiding the PTBP-dependent control of alternative splicing (AS). Whether RAVER1 solely acts in concert with PTBPs and how it affects cancer cell fate remained elusive. Here we provide the first comprehensive investigation of RAVER1-contro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-11 | PXD043342 | Pride
Cancer Emt Raver1 Tgfb Microrna Ptbp Alternative splicing Risc 
TranscriptomicsComparing proteomics and RISC immunoprecipitations to identify targets of Epstein-Barr viral miRNAs [RISC-IP-seq]
Epstein-Barr virus is a gamma-herpes virus that is causally associated with several lymphomas and carcinomas. This virus encodes at least 25 pre-miRNAs, which are expressed in infected cells to yield more than 50 detected mature miRNAs. miRNAs are small, non-coding RNAs that inhibit gene expression ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-46514 | biostudies-arrayexpress
UnknownPrognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort.
Not available
S-EPMC7338015 | biostudies-literature
GenomicsIdentification of microRNA-668 and microRNA-489 targets by RISC immunoprecipitation
Identification of microRNA-668 and microRNA-489 targets by RISC immunoprecipitation
PRJNA483230 | ENA
TranscriptomicsExpression data from HUVEC with YAP siRNA knockdown
YAP knockdown in HUVEC elicits proliferation and cell cycle preogression defects. YAP deficient cells caused arrest in G1 and defects in S-phase entry. The microarray analysis was conducted to identify potential YAP targets that are involved in HUVEC cell cycle regulation mRNA samples were collected...
ORGANISM(S): Homo sapiens 
2014-10-17 | E-GEOD-61989 | biostudies-arrayexpress
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