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ProteomicsIdentification of ribosome proteins bound to IRES in hypoxia
Hypoxic conditions prompt internal ribosome entry site (IRES)-mediated translation of some of the hallmark cancer genes, such as VEGF. This translational switch is extremely vital for cell survival and tumor progression. Heterogeneity in ribosomes due to the diversity of ribosomal RNA (rRNA) and pro...
ORGANISM(S): Homo sapiens (Human) 
2021-01-06 | PXD019238 | Pride
Hypoxia Cancer Ires Lc-ms Ribosome 
ProteomicsIdentification of human FGF9 IRES interacting proteins
We have previously shown that FGF9 is overexpressed in hypoxia through the IRES located in the 5’UTR. To identify the protein that binds to FGF9 IRES and controls FGF9 protein synthesis in hypoxia, FGF9 IRES RNA was in vitro synthesized and used to pulled-down interacting proteins. The RNA-protein c...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012892 | Pride
Human Maldi-tof ms Ires Hypoxia Fgf9 
ProteomicsIRES-dependent ribosome repositioning directs translation of a +1 overlapping ORF that enhances viral infection
Elucidation of a novel +1 frame translational mechanism from the CrPV intergenic region IRES.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-11-22 | PXD011388 | Pride
Ires Drosophila Virus Crpv Translation 
TranscriptomicsIRES containing mRNAs and mitotic cell cycle
A cell synchronization protocol was established in which global and individual mRNA translational efficiencies could be examined. While global translational efficiency was reduced in mitotic cells, approximately 3% of mRNAs remained predominantly associated with large polysomes during mitosis, as de...
ORGANISM(S): Homo sapiens 
2005-12-30 | E-GEOD-3957 | biostudies-arrayexpress
TranscriptomicsPolysome purified mRNA in control and RACK1 silenced in human hepatocarcinoma cells
Fighting viral infections is hampered by the scarcity of viral targets and their variability resulting in development of resistance. Viruses depend on cellular molecules for their life cycle, which are attractive alternative targets, provided that they are dispensable for normal cell functions. Usin...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60374 | biostudies-arrayexpress
GenomicsA versatile IRES toolbox to determine IRES-like activity exemplified by Hoxa mRNA expression and translation in mouse embryonic tissues
A versatile IRES toolbox to determine IRES-like activity exemplified by Hoxa mRNA expression and translation in mouse embryonic tissues
PRJNA1052683 | ENA
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of Sox9+/IRES-EGFP and Sox9+/Y440X-IRES-EGFP Limbs Transcriptomes
Next Generation Sequencing Facilitates Quantitative Analysis of Sox9+/IRES-EGFP and Sox9+/Y440X-IRES-EGFP Limbs Transcriptomes
PRJNA830521 | ENA
GenomicsDifferential IRES-initiated translation during homeostatic stem cell differentiation and stress
Differential IRES-initiated translation during homeostatic stem cell differentiation and stress
PRJNA1162885 | ENA
GenomicsPervasive translation of circular RNAs driven by short IRES-like elements
Pervasive translation of circular RNAs driven by short IRES-like elements
PRJNA639721 | ENA
TranscriptomicsIdentification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors
Translation is a tightly regulated and is predominantly controlled at the level of its initiation. Initiation occurs in a cap-dependent manner. Under stress conditions when cap-dependent translation is hampered, internal ribosome entry sites (IRESes) allow for cap-independent translation of certain ...
ORGANISM(S): Homo sapiens 
2018-01-23 | GSE97159 | GEO
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