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ProteomicsProtein microarray-based autoantibody screening in 51 APS1 patients and 21 healthy controls
Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features multiple autoimmune disease manifestations. It is caused by mutations in the Autoimmune regulator (AIRE) gene, which promote thymic display of thousands of peripheral tissue antigens in a process critical for estab...
ORGANISM(S): Homo sapiens 
2019-06-27 | E-MTAB-8097 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of a backcross between experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains to identify expression quantitative trait loci.
The aim of the experiment is to characterize the genetics and mechanisms of the inflammatory response after induction of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, by studying the genome wide expression in the spleen in late disease. A backcross was created betwe...
ORGANISM(S): Rattus norvegicus 
2013-08-10 | E-MTAB-784 | biostudies-arrayexpress
TranscriptomicsGene Expression Signature Shared in Autoimmune Diseases Not in Unaffected Family Members
Even though autoimmune diseases are heterogeneous, believed to result from the interaction between genetic and environmental components, patients with these disorders exhibit reproducible patterns of gene expression in their peripheral blood mononuclear cells. A portion of this gene expression profi...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-3447 | biostudies-arrayexpress
TranscriptomicsGenetically-driven target tissue over-expression of CD40: A novel mechanism in autoimmune disease
The CD40 gene, an important immune regulatory gene, is also expressed and functional on non-myeloid derived cells, many of which are targets for tissue specific autoimmune diseases, including d thyroid follicular cells in Graves’ disease (GD). Whether target tissue CD40 expression plays a role in au...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39081 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains stimulated with myelin oligodendrocyte glycoprotein (MOG) to identify the alternative splicing.
Experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rats were immunized with myelin oligodendrocyte glycoprotein (MOG) to induce an autoimmune response.
Seven days later draining inguinal lymph nodes were removed. 2 conditions were examined: 'ex vivo' and 'MOG res...
ORGANISM(S): Rattus norvegicus 
2009-11-01 | E-MEXP-2237 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of monocytes and microglia from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course
The role of microglia and infiltrating monocytes in experimental autoimmune encephalomyelitis (EAE) pathogenesis has been controversial. To gain insight into their respective roles, we developed a method for differentiating between microglia and infiltrating monocytes in the CNS using CD44. We used ...
ORGANISM(S): Mus musculus 
2014-10-20 | E-GEOD-59725 | biostudies-arrayexpress
TranscriptomicsGene expression data from polarized T helper cells isolated from mice with opticospinal (OSE) experimental autoimmune encephalomyelitis (EAE)
T cells from the spleen of a mixed-gender pool of four double-transgenic 2D2 (TCRMOG) x IgHMOG mice (OSE) mice, which spontaneously develop experimental autoimmune encephalomyelitis (EAE), were used to derive TH1- and TH17-polarized cells, as described in https://doi.org/10.1371/journal.pone.0015531...
ORGANISM(S): Mus musculus 
2020-08-21 | E-MTAB-9133 | biostudies-arrayexpress
TranscriptomicsGene Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
Myelin Basic Protein (MBP) induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat, produces an an acute weakness, or paralysis of the tail and hind limb ataxia ,weakness or paralysis associated with increased permiability of the blood brain barrier, inflammation and demyelination i...
ORGANISM(S): Rattus norvegicus 
2013-04-03 | E-GEOD-39119 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in acute murine autoimmune hepatitis
The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-β1-/- mice, to identify gene expression pathways...
ORGANISM(S): Mus musculus 
2009-02-28 | E-GEOD-9892 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spinal cords from B10.PL mice with severe (stage 2.5-3) experimental autoimmune encephalomyelitis treated with placebo or 1,25-dihydroxyvitamin D3 to study the molecular mechanism of the compound.
B10.PL mice with severe (stage 2.5-3) experimental autoimmune encephalomyelitis were treated with placebo or 200 ng 1,25(OH)2D3. Six hours later, the spinal cords were harvested and mRNA was extracted for microarray analysis. Naive mice serve as controls. Individual samples were hybridized to ind...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-842 | biostudies-arrayexpress
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