Sort   by:  
 Page size 
ProteomicsA Lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins
Acute lysosomal membrane damage reduces the cellular population of functional lysosomes. However, these damaged lysosomes have a remarkable recovery potential independent of lysosomal biogenesis and remain unaffected in TFEB/TFE3-depleted cells. We combined proximity labelling based proteomics, bioc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-07 | PXD040191 | Pride
Autophagy Lysosomal regeneration Lysosomes Autophagic lysosomal reformation Tbc family of proteins 
ProteomicsLOSS OF THE BATTEN DISEASE PROTEIN CLN3 LEADS TO MIS-TRAFFICKING OF M6PR AND DEFECTIVE AUTOPHAGIC-LYSOSOMAL REFORMATION
Batten disease, one of the most devastating types of neurodegenerative lysosomal storage disorders, is caused by mutations in CLN3. Here, we show that CLN3 is a vesicular trafficking hub connecting the Golgi and lysosome compartments. Proteomic analysis reveals that CLN3 interacts with several endo-...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD031582 | Pride
Human Cln3 Batten Lysosome 
UnknownLoss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.
Not available
S-EPMC10317969 | biostudies-literature
UnknownSpastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.
Not available
S-EPMC4348974 | biostudies-literature
UnknownA conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
Not available
S-EPMC11062384 | biostudies-literature
UnknownAutophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.
Not available
S-EPMC5179940 | biostudies-literature
UnknownTargeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics.
Not available
S-EPMC8416139 | biostudies-literature
UnknownMouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.
Not available
S-EPMC8632344 | biostudies-literature
TranscriptomicsMultiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, manifests in com...
ORGANISM(S): Homo sapiens 
2023-04-17 | GSE223292 | GEO
UnknownDefective lysosome reformation during autophagy causes skeletal muscle disease.
Not available
S-EPMC7773396 | biostudies-literature
Sort   by:  
 Page size