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MetabolomicsAdaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats

Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we ...

2022-04-22 | MTBLS4161 | MetaboLights
MetabolomicsUntargeted lipidomics analysis of yeast metabolic proteins degradations to investigate the role of metabolic proteins in lipid metabolism
We combine auxin-inducible degradation of 500 characterized and 204 uncharacterized proteins with untargeted lipidomics providing a quantitative readout of cellular lipidomic states.
2026-03-24 | MTBLS14098 | MetaboLights
ProteomicsRapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons
Auxin-inducible degrons are a chemical genetic tool for targeted protein degradation and are widely used to study protein function in cultured mammalian cells. Here, we develop CRISPR-engineered mouse lines that enable rapid and highly specific degradation of tagged endogenous proteins in vivo. Most...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-07 | PXD032374 | Pride
Dia Condensin Auxin degradation 
ProteomicsVariation in auxin sensing guides AUX/IAA repressor ubiquitylation and destruction
Auxin is a drug-like small molecule and morphogen that triggers the formation of SCFTIR1/AFB-AUX/IAA co-receptor complexes leading to ubiquitylation and proteasome-dependent degradation of AUX/IAA transcriptional repressors in plants. Here, we systematically dissect auxin sensing by SCFTIR1-IAA6 and...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-06-14 | PXD004027 | Pride
Phytohormone Ubiquitylation Auxin Scf-type e3 ligase Ubiquitination Tir1/afbs Proteolysis Aux/iaa 
TranscriptomicsTranscriptome profiling of A. thaliana expressing auxin degradation resistant IAA26-P108H-GFP from the IAA26 native promoter
The goal of this study was to compare the transcriptional profile (RNA-seq) of seven-week-old auxin resistant pIAA26::IAA26-P108H-GFP transgenic plants to non-transformed control plants to identify candidate genes and pathways regulated by IAA26. RNA-seq analysis was performed with A. thaliana ecoty...
ORGANISM(S): Arabidopsis thaliana 
2016-04-14 | E-GEOD-75983 | biostudies-arrayexpress
ProteomicsDecoding novel acquired resistance mechanisms in auxin-inducible protein degradation
Loss of function studies played a critical role in dissecting gene function and downstream regulation networks. However, the most used knockout approaches, including CRISPR/Cas9, Cre/LoxP, shRNAs, and more, require days to achieve protein depletion. This will lead to the concern of the secondary eff...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD060834 | Pride
Lc-msms 
GenomicsDeciphering resistance mechanisms to auxin-inducible protein degradation in mammalian cells [RNA-Seq]
Deciphering resistance mechanisms to auxin-inducible protein degradation in mammalian cells [RNA-Seq]
PRJNA1226232 | ENA
TranscriptomicsEffect of auxin signaling on Pseudomonas syinrgae pv tomato DC3000 response
Expression data 24hrs after PstDC3000 inoculation in Col-0, 35S:AFB1 and 35S:miR393. We used microarrays to investigated the effect of auxin signaling on PstDC3000 response. Keywords: Alexandre,Robert-Seilaniantz Plants were syringe infiltrated with 10^6cfu/ml of PstDc3000 or water. Leaves were har...
ORGANISM(S): Arabidopsis thaliana 
2009-10-31 | E-GEOD-17500 | biostudies-arrayexpress
GenomicsDeciphering resistance mechanisms to auxin-inducible protein degradation in mammalian cells [ChIP-Seq]
Deciphering resistance mechanisms to auxin-inducible protein degradation in mammalian cells [ChIP-Seq]
PRJNA1314713 | ENA
TranscriptomicsRNA-seq data of mouse embryonic stem cells treated with auxin for CHD4 depletion against untreated control
This study investigates the role of the chromatin remodeller CHD4 in regulating gene expression. CHD4 was tagged with a mini-AID degron to enable auxin-inducible degradation. RNA-seq was performed at multiple time-points (1, 2, 4 and 24 hours) following auxin treatment to capture changes in gene exp...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15102 | biostudies-arrayexpress
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