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TranscriptomicsEGF decreases the abundance of microRNAs that restrain oncogenic transription factors
Epidermal growth factor (EGF) stimulates cells by launching gene expression programs that are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by binding complementary regions in messenger RNAs, are broadly implicated in cancer. Using genome-wide approaches, we showed tha...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-40626 | biostudies-arrayexpress
TranscriptomicsAnalysis of bacterial and macrophage transcripts in ISRE-positive and negative infected macrophages
To identify bacterial transcripts that may be associated with type I IFN production in Salmonella enterica subsp typhimurium (SL1344) infected macrophages we transformed macrophages with an ISRE-GFP reporter construct and sorted separate populations of GFP positive and GFP negative infected macropha...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65531 | biostudies-arrayexpress
TranscriptomicsSingle cell analysis of macrophages exposed to beads coated with LPS from Salmonella enterica subsp. typhimurium
We present a detailed single cell analysis of the macrophage response to LPS from Salmonella enterica. By combining single cell transcriptional analysis, fluorescently labeled, LPS-coated beads, and cytometry we are able to distinguish the responses of macrophages that have internalized LPS-coated ...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65529 | biostudies-arrayexpress
TranscriptomicsSingle cell time course of macrophages exposed to Salmonella enterica subsp. typhimurium
We present a detailed single cell time course of the macrophage response to Salmonella infection. By combining phenotypic fluorescent labels with single cell expression analysis we are able to identify gene modules associated with bacterial exposure and bacterial infection. We also identify other ...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65528 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq analysis of the macrophage response to Salmonella enterica subsp. Typhimurium (SL1344) exposure
A time course of the macrophage response to Salmonella exposure analyzing the effects of input cell number as a control for single cell studies Mouse macrophages were exposed to Salmonella enterica for different lengths of time. Libraries were constructed using either approximately 500,00 macrophag...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65530 | biostudies-arrayexpress
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
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