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ProteomicsAXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
Axis inhibition protein 1 (AXIN), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify AXIN acts as an effective regulator of antiviral in...
ORGANISM(S): Homo sapiens (Human) 
2024-10-31 | PXD055972 | Pride
Human Irf3 Axin1 
ProteomicsAXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
Axis inhibition protein 1 (AXIN), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify AXIN acts as an effective regulator of antiviral in...
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD055574 | Pride
Human Irf3 Axin1 
ProteomicsAP-MS of different isoforms of Axin
This project aims to identify and differentiate the interaction partners of Axin1 isoforms including 1 wild type and 3 different mutants (L106R, L106R_F119R, deltaRGS).
ORGANISM(S): Homo sapiens (Human) 
2016-02-26 | PXD003116 | Pride
Ap-ms Wnt signaling Axin1 Proteomics Hek293 
ProteomicsAP-MS of different isoforms of Axin
This project aims to identify and differentiate the interaction partners of Axin1 isoforms including 1 wild type and 3 different mutants (L106R, L106R_F119R, deltaRGS)
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD001822 | Pride
Ap-ms Wnt signaling Axin1 Proteomics Hek293 
ProteomicsRas-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.
In this study, we deciphered cellular mechanisms underlying AXIN1 loss by MEK1/2 inhibition in colorectal cancer (CRC). We observed that both MEK1/2 and GSK3B inhibitors strongly reduce AXIN1 levels across multiple CRC models. Inhibition of MEK1/2, but not GSK3B, causes a reduction of AXIN1 transcri...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD067308 | Pride
Gsk3b inhibition Mek inhibition Hct116 Immunoprecipitation Lc-ms/ms Colorectal cancer 
GenomicsCRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines
Unraveling the Impact of AXIN1 Mutations on HCC Development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines
PRJEB64131 | ENA
GenomicsBreast Cancer Suppressor Role of RUNX1: Estrogen-dependent Regulation of AXIN1 and b-catenin
The transcription factor RUNX1 exhibits recurrent loss-of-function mutations in estrogen receptor-positive (ER+) breast cancer (BCa). Its knockdown in vitro decreased AXIN1 expression in estrogen-dependent manner. Consistently, RUNX1 and AXIN1 mRNA levels are strongly correlated in ER+, not ER- tu...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-65313 | biostudies-arrayexpress
GenomicsExpression alterations induced by restoration of AXIN1 expression in SNU449 hepatocellular carcinoma cells
Expression alterations induced by restoration of AXIN1 expression in SNU449 hepatocellular carcinoma cells
PRJNA487644 | ENA
TranscriptomicsGene expression in homozygous mbl/axin1 zebrafish
Homozygous masterblind (mbl-/-) zebrafish exhibit reduced or absent eyes and telecephalon, and the expansion of the diencephalic fates to the front of the brain. A missense mutation in the GSK3-binding domain of zebrafish axin1, a scaffolding protein in the Wnt signaling pathway, results in the mbl ...
ORGANISM(S): Danio rerio 
2007-04-27 | GSE6142 | GEO
GenomicsExpression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice
Expression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice
PRJNA419918 | ENA
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