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MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
TranscriptomicsCharacterising the transcriptional profile of murine 3T3-L1 adipocytes with altered expression of IRF3.
The chronic inflammatory state that accompanies obesity is a major contributor to insulin resistance and other metabolic dysfunction features. Despite recent advances in our understanding of the cellular and secreted factors that promote the inflammatory milieu of obesity, we have much less insight ...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-81193 | biostudies-arrayexpress
ProteomicsAXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
Axis inhibition protein 1 (AXIN), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify AXIN acts as an effective regulator of antiviral in...
ORGANISM(S): Homo sapiens (Human) 
2024-10-31 | PXD055972 | Pride
Human Irf3 Axin1 
ProteomicsAXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
Axis inhibition protein 1 (AXIN), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify AXIN acts as an effective regulator of antiviral in...
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD055574 | Pride
Human Irf3 Axin1 
ProteomicsIdentification of IRF3 hydroxylation site
Identification of IRF3 hydroxylation site in cells
ORGANISM(S): Homo Sapiens 
2024-03-12 | PXD050566 |
TranscriptomicsThe IRF3 dependent response of macrophages to M. tuberculosis infection
Transcriptional profiling of macrophages (wild-type and IRF3-/- ) infected with various M.tuberculosis strains (wild-type and ESX-1 mutant) Comparison of the global gene expression of wild-type BMDM macrophages and IRF3-/- macrophages infected with either wild-type M.tuberculosis or ESX-1 mutant M.t...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-36686 | biostudies-arrayexpress
ProteomicsIRF3 and HIF hydroxylation by EGLN1
Identification of IRF3 and HIF-1α hydroxylation site(s) by mass spectrometry
ORGANISM(S): Homo Sapiens 
2024-03-21 | PXD048667 |
TranscriptomicsGene expression in IRF3-/- peritoneal macrophage infected with VSV
IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and RIG-I-like receptor) signalling pathway. IRF3 is known to induce the expression of type I IFN gene upon virus infection. To furter examine the role of IRF3 in virus-i...
ORGANISM(S): Mus musculus 
2012-05-19 | E-GEOD-37855 | biostudies-arrayexpress
GenomicsIRF3-binding RNA RIP-seq
IRF3-binding RNA RIP-seq
PRJNA576866 | ENA
GenomicsMacropahge-specific Irf3 prevents viral inflammation
Macropahge-specific Irf3 prevents viral inflammation
PRJNA1112164 | ENA
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