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ProteomicsGas6/Axl signaling activates Akt in liver cancer cells
We investigated which signaling pathways downstream of Gas6/Axl promote the invasive phenotype of liver cancer cells. Thus, we performed phospho-proteomic analysis of MR hepatocytes and those expressing Axl (MR-Axl) in the presence and absence of Gas6. Protein-clustering based on the pattern of phos...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047577 | Pride
Cell invasion Axl Hepatocellular carcinoma. Gas6 
ProteomicsIntegrated proteomics-based physical and functional mapping of AXL kinase signaling pathways and inhibitors define its role in cell migration: BioID
To better understand the signaling complexity of AXL, a member of the TAM family of receptor tyrosine kinases, we created a physical and functional map of AXL signaling interactions, phosphorylation events, and target-engagement of three AXL tyrosine kinase inhibitors (TKI). We assessed AXL protein-...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD023911 | Pride
Lung cancer Targeted therapy Bioid Axl tyrosine kinase 
ProteomicsN-glycosylation of AXL receptor tyrosine kinase regulates its stability, phosphorylation and oncogenic function
AXL, a receptor tyrosine kinase implicated in tumor progression, undergoes post-translational modifications that regulate its activity and stability. In this study, we have analyzed AXL immunoprecipitated from cell lines by liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based glycoproteom...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071027 | Pride
Receptor tyrosine kinase Phosphorylation Axl N-glycosylation Proliferation 
ProteomicsIntegrated proteomics-based physical and functional mapping of AXL kinase signaling pathways and inhibitors define its role in cell migration: Phosphoproteomics
To better understand the signaling complexity of AXL, a member of the TAM family of receptor tyrosine kinases, we created a physical and functional map of AXL signaling interactions, phosphorylation events, and target-engagement of three AXL tyrosine kinase inhibitors (TKI). We assessed AXL protein-...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD023923 | Pride
Phosphoproteomics Lung cancer Targeted therapy Axl tyrosine kinase 
ProteomicsDissecting early AXL signaling regulators and associated phenotypes in erlotinib-treated EGFR mutant lung cancer by phophosite perturbations
Targeted therapies for receptor tyrosine kinases are effective but invariably limited by drug resistance. In EGFR-mutant lung cancer, AXL activation drives resistance to erlotinib by restoring cell survival and migration. To map these signaling mechanisms, we generated a panel of lung adenocarcinoma...
ORGANISM(S): Homo sapiens (Human) 
2026-06-14 | PXD079076 | Pride
Computational modeling Axl Luad Drug resistance Kinase biology Systems biology Egfr 
GenomicsGas6-Axl signaling drives oral regenerative wound repair
Gas6-Axl signaling drives oral regenerative wound repair
PRJNA1212540 | ENA
ProteomicsIntegrated proteomics-based physical and functional mapping of AXL kinase signaling pathways and inhibitors define its role in cell migration: ABPP
To better understand the signaling complexity of AXL, a member of the TAM family of receptor tyrosine kinases, we created a physical and functional map of AXL signaling interactions, phosphorylation events, and target-engagement of three AXL tyrosine kinase inhibitors (TKI). We assessed AXL protein-...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD023913 | Pride
Abpp Lung cancer Targeted therapy Axl tyrosine kinase 
ProteomicsQuantitative tyrosine phosphoproteome profiling of GAS6-AXL signaling network
Overexpression and amplification of AXL receptor tyrosine kinase (RTK) has been found in several hematologic and solid malignancies. Activation of AXL by its ligand GAS6 can enhance tumor-promoting processes such as proliferation, migration, invasion, and survival. Despite the important role of AXL ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-24 | PXD025457 | Pride
Breast cancer Tmt Axl Phosphorylation Mas spectrometry 
TranscriptomicsIdentification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA (gene expression)
Triple negative breast cancer (TNBC) is histologically characterized by the absence of the hormone receptors estrogen and progesterone, in addition to having a negative immunostain for HER-2. The aggressiveness of this disease and lack of targeted therapeutic options for treatment is of high clinic...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21832 | biostudies-arrayexpress
GenomicsGas6-Axl signaling drives oral regenerative wound repair [bulk RNA]
Gas6-Axl signaling drives oral regenerative wound repair [bulk RNA]
PRJNA1214801 | ENA
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