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ProteomicsMapping Axon Initial Segment Structure and Function by Iterative Proximity Biotinylation
We constructed AIS-targeted biotin ligase by generating fusion proteins of BirA* with NF186, Ndel1, and Trim46; these chimeras mapped the molecular organization of intracellular membrane, cytosolic, and microtubule compartments of the AIS, respectively
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-13 | PXD016272 | Pride
Bioid Axon initial segments 
ProteomicsTRIM46 Kinase Assay
Phosphoproteomic analysis of recombinant TRIM46 reacted with CDK5 kinase in vitro.
ORGANISM(S): Mus Musculus (mouse) 
2019-08-29 | PXD014109 | JPOST Repository
ProteomicsKAP3 kinase assay
Phosphoproteomic analysis of recombinant KAP3 reacted with MARK2 kinase in vitro.
ORGANISM(S): Mus Musculus (mouse) 
2019-08-29 | PXD014110 | JPOST Repository
TranscriptomicsRNA-Seq of Drosophila melanogaster Cdk12-null mutants versus control
In a forward genetic screen, we have previously identified a null mutant of Cdk12 that results in alterations in actin dynamics, the axon initial segment and electrophysiology in Drosophila melanogaster. To decipher how Cdk12 may be having these effects, we extracted RNA from pooled Drosophila heads...
ORGANISM(S): Drosophila melanogaster 
2023-01-01 | E-MTAB-12090 | biostudies-arrayexpress
UnknownAxon Initial Segments Are Required for Efficient Motor Neuron Axon Regeneration and Functional Recovery of Synapses.
Not available
S-EPMC9636994 | biostudies-literature
GenomicsLoss of Neurofascin 186 and Ankyrin G in Purkinje Cells Causes Disruption of Axon Initial Segments, Neurodegeneration and Cerebellar Ataxia
Loss of Neurofascin 186 and Ankyrin G in Purkinje Cells Causes Disruption of Axon Initial Segments, Neurodegeneration and Cerebellar Ataxia
PRJNA1431379 | ENA
ProteomicsTotal and synaptosomal proteomic analysis
Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-relate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-19 | MSV000091510 | MassIVE
UnknownbetaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG.
Not available
S-EPMC2063985 | biostudies-literature
UnknownNodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms.
Not available
S-EPMC2064285 | biostudies-literature
UnknownPathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental Disorders.
Not available
S-EPMC8392614 | biostudies-literature
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