Sort   by:  
 Page size 
ProteomicshnRNP R promotes O-GlcNAcylation of eIF4G to facilitate axonal protein synthesis
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD052115 | Pride
Rl2 Axonal translation Ogt Interactome Motoneuron 
TranscriptomicsAxonal mRNA in human embryonic stem cell derived neurons
The identification of axonal mRNAs in model organisms has led to the discovery of many axonally translated proteins required for axon guidance and injury response. The extent to which these axonal mRNAs are conserved in humans is unknown. Here we report on the axonal transcriptome of glutamatergic n...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-84975 | biostudies-arrayexpress
GenomicsAxonal ER tubules control local translation via P180/RRBP1-mediated ribosome interactions
Axonal ER tubules control local translation via P180/RRBP1-mediated ribosome interactions
PRJNA1090922 | ENA
TranscriptomicsChanges of axonal transcriptomes in response to local Abeta
We report that local application of Abeta(1-42) for 24h triggers changes in the localized transcriptome, while the transcriptome in cell bodies remains largely unchanged. Axonal and somatic mRNA profiles of rat embryonic hippocampal neurons grown in microfluidic chambers were generated by RNA-Seq in...
ORGANISM(S): Rattus norvegicus 
2015-07-14 | E-GEOD-70860 | biostudies-arrayexpress
GenomicsCPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity
CPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity
PRJNA860927 | ENA
GenomicsLoss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
PRJNA615680 | ENA
TranscriptomicsAxonal ER tubules control local translation via P180/RRBP1-mediated ribosome interactions
Local mRNA translation in axons is critical for the spatial and temporal regulation of the axonal proteome. A wide variety of mRNAs are localized and translated in axons, however how protein synthesis is regulated at specific subcellular sites in axons remains unclear. Here, we establish that the ax...
ORGANISM(S): Rattus norvegicus 
2024-04-29 | GSE262262 | GEO
TranscriptomicsGlobal transcriptome analysis reveals differences between embryonic and adult dorsal root ganglion axonal mRNAs that are implicated in axonal growth and pain
Local protein synthesis in sensory neuron axons is necessary for axonal regeneration with the efficiency of regeneration decreasing with age. Because the full repertoire of transcripts in embryonic and adult rat sensory axons is unknown we asked how the pool of mRNAs dynamically changes during age...
ORGANISM(S): Rattus norvegicus 
2010-11-23 | E-GEOD-22638 | biostudies-arrayexpress
UnknownAxonal cap-dependent translation regulates presynaptic p35.
Not available
S-EPMC4136430 | biostudies-literature
UnknownAxonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration.
Not available
S-EPMC6105716 | biostudies-literature
Sort   by:  
 Page size