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TranscriptomicsExpression data from human endometrial cancer cell line AN3-CA treated with 300 nM AZD4547
AZD4547,pan-FGFR inhibitor, have been reported to have profound therapeutic effects on FGFR-deregulated cancers. AN3-CA is one of endometrial cancer cell lines harbouring FGFR2 mutants. AZD4547 showed a potent antiprolierative effect on AN3-CA cells. we used microarray to investigate transcriptome-...
ORGANISM(S): Homo sapiens 
2015-09-17 | E-GEOD-61481 | biostudies-arrayexpress
ProteomicsTMT-labeled mass spectrometry-based proteomics analysis in NCI-H1581 lung cancer cells upon AZD4547 treatment
FGFR1-amplified lung cancer cell line NCI-H1581 was treated with FGFR inhibitor AZD4547 (0.1μM) or DMSO vehicle for 24 hours. Then TMT-labeled mass spectrometry-based proteomics was carried out in cell lysates to analyze the differentially expressed proteins between two groups.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD032227 | Pride
Tmt-labeled mass spectrometry Azd4547 Nci-h1581 
TranscriptomicsExpression data from human endometrial cancer cell line AN3-CA treated with 300 nM AZD4547
AZD4547,pan-FGFR inhibitor, have been reported to have profound therapeutic effects on FGFR-deregulated cancers. AN3-CA is one of endometrial cancer cell lines harbouring FGFR2 mutants. AZD4547 showed a potent antiprolierative effect on AN3-CA cells. we used microarray to investigate transcriptome-w...
ORGANISM(S): Homo sapiens 
2015-09-17 | GSE61481 | GEO
GenomicsEffect of the FGFR kinase inhibitors AZD4547 and BGJ398 on gene expression in HaCaT cells
Effect of the FGFR kinase inhibitors AZD4547 and BGJ398 on gene expression in HaCaT cells
PRJNA1111790 | ENA
UnknownThe FGFR Family Inhibitor AZD4547 Exerts an Antitumor Effect in Ovarian Cancer Cells.
Not available
S-EPMC8509426 | biostudies-literature
UnknownAnti-Tumor Activity of AZD4547 Against NTRK1 Fusion Positive Cancer Cells Through Inhibition of NTRKs.
Not available
S-EPMC8591201 | biostudies-literature
TranscriptomicsCombined transcriptomic profiling of anti-PD-1 immunotherapy and FGFR inhibitor AZD4547 in a CT26 colorectal cancer syngeneic mouse model
This study investigated the transcriptomic effects of anti-PD-1 immunotherapy combined with the FGFR inhibitor AZD4547 in a CT26 colorectal cancer syngeneic mouse model. BALB/c mice bearing CT26 subcutaneous tumors were randomized into four treatment groups: Rat IgG2a + PBS (control), anti-PD-1 anti...
ORGANISM(S): Mus musculus 
2026-09-26 | GSE347086 | GEO
GenomicsCombined transcriptomic profiling of anti-PD-1 immunotherapy and FGFR inhibitor AZD4547 in a CT26 colorectal cancer syngeneic mouse model
Combined transcriptomic profiling of anti-PD-1 immunotherapy and FGFR inhibitor AZD4547 in a CT26 colorectal cancer syngeneic mouse model
PRJNA1528666 | ENA
UnknownThe FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT.
Not available
S-EPMC6647014 | biostudies-literature
UnknownFGFR inhibitor, AZD4547, impedes the stemness of mammary epithelial cells in the premalignant tissues of MMTV-ErbB2 transgenic mice.
Not available
S-EPMC5595825 | biostudies-literature
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