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Transcriptomicsgamma-catenin (junction plakoglobin, Jup) dependent signals mediate the progression of BCR-ABL1+ B-ALL
The BCR-ABL1 translocation product is the cause of Chronic Myeloid Leukemia (CML) and of a significant fraction of adult-onset B-Acute Lymphoblastic Leukemia (B-ALL) cases. Here we identify an essential role for gamma-catenin (junction plakoglobin) in B lineage restricted cells for the progression o...
ORGANISM(S): Mus musculus 
2014-02-08 | E-GEOD-54793 | biostudies-arrayexpress
ProteomicsCharacterisation of the Beta-Catenin cytoplasmic/nuclear interactome in leukaemia cells
Canonical Wnt/B-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients; however, some patients exhibit little or no β-...
ORGANISM(S): Homo sapiens (Human) 
2019-01-11 | PXD009305 | Pride
Wnt signalling Myeloid B-catenin Interactome Leukaemia 
GenomicsGenome-wide maps of Six2 and b-catenin in mesenchymal nephron progenitors
Self-renewing undifferentiated nephron progenitors express Six2, a transcription factor that is required for their maintenance as undifferentiated progenitors. Differentiation of nephron progenitors is triggered by Wnt/b-catenin signaling. In order to understand how Six2 and Wnt signaling counteract...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-39837 | biostudies-arrayexpress
GenomicsBeta-catenin deletion and GSK3b inhibition in B-ALL cells
Beta-catenin deletion and GSK3b inhibition in B-ALL cells
PRJNA1027763 | ENA
ProteomicsB-catenin downregulates Dicer to promote ovarian cancer metastasis
Ovarian cancer is a nearly uniform lethal disease and its highly aggressive metastatic phenotype portends a poor prognosis. Lack of a well-controlled, relevant experimental model has been a major obstacle to identifying key molecules causing metastasis. Here we describe the creation of a new isogeni...
ORGANISM(S): Homo sapiens (Human) 
2017-07-03 | PXD006327 | Pride
Dicer Ovarian cancer Microrna -catenin Metastasis 
TranscriptomicsThe Leukemia-associated Mllt10/Af10- Dot1l, dedicated b-catenin coactivators essential for intestinal homeostasis
Background: Wnt signaling maintains the undifferentiated state of intestinal crypt progenitor cells by inducing the formation of nuclear TCF4/beta-catenin complexes. In colorectal cancer, activating mutations in Wnt pathway components cause inappropriate activation of TCF4/beta-catenin -driven tran...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-21367 | biostudies-arrayexpress
GenomicsCooperation of MYC and b-catenin in liver tumorigenesis requires Yap/Taz
Cooperation of MYC and b-catenin in liver tumorigenesis requires Yap/Taz
PRJNA575356 | ENA
GenomicsActivation of b-CATENIN in Fibro/Adipogenic Progenitors Leads to Muscle Mass Loss
Activation of b-CATENIN in Fibro/Adipogenic Progenitors Leads to Muscle Mass Loss
PRJNA912742 | ENA
Genomicsb-catenin Signaling Dynamics Regulate Cell Fate in Differentiating Neural Stem Cells
b-catenin Signaling Dynamics Regulate Cell Fate in Differentiating Neural Stem Cells
PRJNA655888 | ENA
GenomicsEnhancement of Transgene Expression by the b-Catenin Inhibitor iCRT14
Enhancement of Transgene Expression by the b-Catenin Inhibitor iCRT14
PRJNA650293 | ENA
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