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ProteomicsAnalysis of the interactome of B2-SINE RNA transcripts
B2-SINEs are noncoding RNAs which are transcribed by RNA polymerase III (Pol III) from short interspersed nuclear elements (SINEs), which are high copy number transposable elements in the mouse genome. Unexpectedly have observed significant induction of non-coding RNAs from the B2-SINE subclass of r...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD041633 | Pride
B2-sine rnas Rna-protein interactions Rna regulators 
ProteomicsAnalysis of the interactome of B2-SINE RNA transcripts
B2-SINEs are noncoding RNAs which are transcribed by RNA polymerase III (Pol III) from short interspersed nuclear elements (SINEs), which are high copy number transposable elements in the mouse genome. Unexpectedly have observed significant induction of non-coding RNAs from the B2-SINE subclass of r...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-05 | PXD060976 | Pride
B2-sine rnas Rna-protein interactions Rna regulators 
GenomicsTargeting GI-SINE (Growth inducing B2-SINE) RNA in DRG neurons by Antisense Oligonucleotides (ASO)
Targeting GI-SINE (Growth inducing B2-SINE) RNA in DRG neurons by Antisense Oligonucleotides (ASO)
PRJNA1090485 | ENA
GenomicsB2 SINE expression during MHV68 infecton
Short interspersed nuclear elements (SINEs) are retrotransposons evolutionarily derived from endogenous RNA Polymerase III RNAs. Though SINE elements have undergone exaptation into gene regulatory elements, how transcribed SINE RNA impacts transcriptional and post-transcriptional regulation is large...
ORGANISM(S): Mus musculus 
2016-10-31 | GSE85518 | GEO
TranscriptomicsTargeting GI-SINE (Growth inducing B2-SINE) RNA in DRG neurons by Antisense Oligonucleotides (ASO)
We identified 2 specific motifs that are enriched in GI-SINE RNA expressed in sciatic-nerve injured DRG neurons compared to non-regulated B2-SINE RNAs. We designed a mix of 5 ASOs (21nt phosphorothioate DNA with LNA-flanks) that target these motifs and transfected those into cultured dorsal root gan...
ORGANISM(S): Mus musculus 
2025-05-16 | GSE262153 | GEO
TranscriptomicsIncreased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathology
More than 97% of the mammalian genome is non-protein coding, and repetitive elements account for more than 50% of noncoding space. However, the functional importance of many non-coding RNAs generated by these elements and their connection with pathologic processes remains elusive. We have previously...
ORGANISM(S): Mus musculus 
2020-11-19 | GSE149243 | GEO
TranscriptomicsDifferential adenosine to inosine RNA editing of SINE B2 non-coding RNAs in mouse unveils a novel type of epi-transcriptome response to amyloid beta neuro-toxicity
Alzheimer's disease (AD) is characterized by early molecular responses to amyloid beta neuro-toxicity that remain poorly defined. RNA editing by adenosine-to-inosine (A-to-I) conversion is a major epitranscriptomic mechanism, yet its contribution to non-coding RNA regulation during neurodegeneration...
ORGANISM(S): Mus musculus 
2026-06-12 | GSE316378 | GEO
GenomicsIncreased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathology
Increased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathology
PRJNA627718 | ENA
GenomicsDifferential adenosine to inosine RNA editing of SINE B2 non-coding RNAs in mouse unveils a novel type of epi-transcriptome response to amyloid beta neuro-toxicity
Differential adenosine to inosine RNA editing of SINE B2 non-coding RNAs in mouse unveils a novel type of epi-transcriptome response to amyloid beta neuro-toxicity
PRJNA1402396 | ENA
UnknownIncreased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology.
Not available
S-EPMC7717908 | biostudies-literature
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