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TranscriptomicsMicroarray expression profiling of the Igf2 pathway dependency of Trp53 developmental and tumour phenotypes in mice
We tested whether loss of p53 function leads to insulin-like growth factor 2 (IGF2) pathway dependency in vivo in genetically defined mouse models. Unexpectedly we found lethality, due to post-natal lung haemorrhage, occurred in Igf2 paternal null allele female mice (Igf2-p) but only if derived from...
ORGANISM(S): Mus musculus 
2012-06-01 | E-MTAB-1001 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mdx animals expressing high levels of utrophin therapeutic implications for DMD
Duchenne Muscular Dystrophy (DMD) is a fatal muscle wasting disorder caused by dystrophin deficiency. Previous work suggested that increased expression of the dystrophin-related protein utrophin in the mdx mouse model of DMD can prevent dystrophic pathophysiology. Physiological tests showed that t...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7187 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphatic endothelial cells, mouse dermal cells and human skin cells reveals an inflammation-induced mechanism for leukocyte transmigration of lymphatic vessel endothelium.
The exit of antigen-presenting cells (APC) and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. How such exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels is however unknown. Here we show ...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-6257 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T241/VEGF-C/GFP metastatic fibrosarcoma reveals lymphatic endothelium of metastatic tumours has a distinct transcription profile.
Invasion of lymphatic vessels is a key step in the metastasis of primary tumour cells to draining lymph nodes. Recent evidence indicates that such metastasis can be facilitated by tumour lymphangiogenesis, although it remains unclear whether this is a consequence of increased lymphatic vessel number...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-6255 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+ memory T cells reveals they are preferential targets for bystander activation and apoptosis
There is much evidence that T cells may be activated via mechanisms which act independently of direct TCR ligation. Despite this, the question of whether such forms of ‘bystander’ T cell activation occur during immune responses is hotly debated. To address some outstanding questions, we set up ...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-13738 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans after infection with Microbacterium nematophilum
Genomic response of C. elegans after infection with Microbacterium nematophilum.

The interaction between the nematode Caenorhabditis elegans and a Gram-positive bacterial pathogen, Microbacterium nematophilum, provides a model for an innate immune response in nematodes. This pathogen adheres ...
ORGANISM(S): Caenorhabditis elegans 
2005-01-01 | E-MEXP-696 | biostudies-arrayexpress
TranscriptomicsJMJD2B knockdown treatment in normoxia and hypoxia
Estrogen receptor alpha plays a critical role in breast cancer and is a major target in endocrine therapy. HIF-1 alpha have been associated with ER alpha and predict a worse outcome. Recent studies indicate that histone demethylase JMJD2B is a HIF-1 alpha target. However, little is known about the b...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-18384 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse testicular response to recombinant follicle stimulating hormone (rFSH) in hypogonadal males
In the normal mouse the pituitary gonadotrophins determine development, maturation and physiological regulation of the testis with follicle-stimulating hormone (FSH) activating the Sertoli cell and luteinising hormone (LH) the Leydig cell. To look at the potential interaction of cell types within t...
ORGANISM(S): Mus musculus 
2009-08-22 | E-GEOD-8924 | biostudies-arrayexpress
TranscriptomicsTo compare the expression profile of CD8 T cells from mice vaccinated with Ad85A via the intranasal (IN) or intradermal (ID) routes isolated from lungs or spleen.
In Balb/c mice, the presence of effector CD8 T cells in lungs after intra-nasal (IN) immunization with replication deficient recombinant Adenovirus expressing the 85A antigen from Mycobacterium tuberculosis (MTb) (Ad85A) correlates with protection against aerosol MTb infection. In order to identify ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-23713 | biostudies-arrayexpress
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