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ProteomicsCSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD032782 | Pride
Cerebrospinal fluid Bace Alzheimer disease Appps1 Csf 
ProteomicsPharmacoproteomics of non-human primate cerebrospinal fluid after BACE inhibition
The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive worsening that may be caused by modulation of unknown physiological BACE1 substrates. To identify in vivo-relevant BACE1 substrates we applied pharmacoproteomics to non-...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2023-02-23 | PXD035141 | Pride
Bace Beta secretase Cerebrospinal fluid Alzheimer's disease Csf 
GenomicsBace-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
Bace-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
PRJNA851913 | ENA
ProteomicsPlasma proteomics of mice treated with BACE inhibitors
The Beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. To discover potential BAC2 substrates in plasma, mice wer...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD042669 | Pride
Bace Plasma Mus musculus 
ModelsRong2020 - Grover-Bace: Prediction of Beta-secretase 1 (BACE-1) inhibition.
Prediction of Beta-secretase 1 (BACE-1) inhibition. BACE-1 is expressed mainly in neurons and has been involved in the development of Alzheimer's disease. This model has been trained on the BACE dataset from MoleculeNet using the GROVER transformer. Model Type: Predicitive machine learning model. ...
2024-06-05 | MODEL2406050003 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
TranscriptomicsBace-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
Single-cell RNA sequencing data from purified mouse microglia with and without 5xFAD Alzheimer's disease model and with and without Bace-1 knockout
ORGANISM(S): Mus musculus 
2022-06-22 | GSE199027 | GEO
UnknownDepletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
Not available
S-EPMC1973166 | biostudies-literature
UnknownMolecular docking analysis of marine phytochemicals with BACE-1.
Not available
S-EPMC10941776 | biostudies-literature
UnknownSurface Trafficking of APP and BACE in Live Cells.
Not available
S-EPMC6680167 | biostudies-literature
UnknownBACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1.
Not available
S-EPMC9205595 | biostudies-literature
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