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GenomicsRNAseq of cortex of 6-month old APPPS1 and APPPS1 Apoe-/- mice
RNAseq of cortex of 6-month old APPPS1 and APPPS1 Apoe-/- mice
PRJNA432321 | ENA
ProteomicsCSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD032782 | Pride
Cerebrospinal fluid Bace Alzheimer disease Appps1 Csf 
ProteomicsMicroglial proteomic signatures in APPPS1 and APP-KI mice
Microglial dysfunction is a key pathological feature of Alzheimer´s disease (AD), but little is known about proteome-wide changes in microglia during the course of AD pathogenesis and their consequences for microglial function. Here, we performed an in-depth proteomic characterization of microglia i...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-09 | PXD016075 | Pride
Neuroinflammation Phagocytosis Alzheimer’s disease Proteomic signatures Microglia 
TranscriptomicsExpression profiling of laser-microdissected tissue from APPPS1 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15058 | biostudies-arrayexpress
ProteomicsCerebrospinal Fluid (CSF) Proteomics of APPPS1 mice
Here, we took advantage of well-defined mouse models for β-amyloidosis (APPPS1) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo a...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-21 | PXD021322 | Pride
Mouse Appps1 Alzheimer Amyloid beta 
ProteomicsAltered Brain Energy Metabolism in the APPPS1 Alzheimer’s Mouse Model during Anesthesia
Background: Synaptic transmission and network activity rely on high ATP turnover. Impairments in cerebral energy metabolism are increasingly recognized as central to aging and the pathogenesis of Alzheimer’s disease (AD). AD is related to elevated risk for perioperative neurological complications, i...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD072113 | Pride
TranscriptomicsRNAseq of cortex of 6-month old APPPS1 and APPPS1;Apoe-/- mice
One of the hallmarks of Alzheimer’s disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ) peptide. ApoE influences the deposition of amyloid pathology through affecting the clearance and aggregation of monomeric Aβ in the brain. In addi...
ORGANISM(S): Mus musculus 
2018-02-15 | GSE109906 | GEO
UnknownChronic stress induces NPD-like behavior in APPPS1 and WT mice with subtle differences in gene expression.
Not available
S-EPMC9285501 | biostudies-literature
GenomicsSingle nucleus RNA sequencing of the cortex of antibiotic and vehicle treated APPPS1-21 mice
Single nucleus RNA sequencing of the cortex of antibiotic and vehicle treated APPPS1-21 mice
PRJNA1254715 | ENA
GenomicsThe effect of antibiotics and propionate treatment on astrocyte transcription in APPPS1-21 mice
The effect of antibiotics and propionate treatment on astrocyte transcription in APPPS1-21 mice
PRJNA1254711 | ENA
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