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ProteomicsGenome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
Brain metastasis occurs in up to 40% of patients with non-small cell lung cancer (NSCLC). Considerable genomic heterogeneity exists between the primary lung tumor and respective brain metastasis; however, the identity of the genes capable of driving brain metastasis is incompletely understood. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD060790 | Pride
Bace1 Egfr 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067413 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067461 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsSurface glycoproteome of BACE1-inhibited neurons
The cell surface proteome is dynamic and has fundamental roles in cell signaling. Many surface membrane proteins are proteolytically released into a cell’s secretome, where they can have additional functions in cell-cell-communication. Yet, it remains challenging to determine the surface proteome an...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-08 | PXD008619 | Pride
Bace1 Surface N-glycoproteome Murine neurons 
TranscriptomicsAge- and Obesity Induced Decline of Brown Fat Function as Consequence of Impaired miR-328 Dependent Silencing of Bace1
Activated brown adipose tissue contributes to control of energy and glucose homeostasis in rodents and humans. Defining cell-autonomous processes underlying BAT differentiation and activation may thus reveal novel therapeutic targets for obesity and type 2 diabetes mellitus intervention. Here we sho...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-69913 | biostudies-arrayexpress
UnknownInhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression.
Not available
S-EPMC11324814 | biostudies-literature
UnknownBACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage.
Not available
S-EPMC8532805 | biostudies-literature
GenomicsRamalin ameliorates Alzheimer's disease pathology by targeting BACE1, HDAC6, and MAPK pathways
Ramalin ameliorates Alzheimer's disease pathology by targeting BACE1, HDAC6, and MAPK pathways
PRJNA1303134 | ENA
UnknownBACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.
Not available
S-EPMC5904228 | biostudies-literature
UnknownInhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation.
Not available
S-EPMC10457076 | biostudies-literature
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