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ProteomicsGenome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
Brain metastasis occurs in up to 40% of patients with non-small cell lung cancer (NSCLC). Considerable genomic heterogeneity exists between the primary lung tumor and respective brain metastasis; however, the identity of the genes capable of driving brain metastasis is incompletely understood. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD060790 | Pride
Bace1 Egfr 
ProteomicsIdentifying the BACE1 interactome through BioID proximity assay
This study used the BioID proximity assay to establish the BACE1 interactome in healthy neuronal cells and identified interactions involved in BACE1 trafficking, post-translational modification and substrates.
ORGANISM(S): Mus musculus (Mouse) 
2021-12-30 | PXD021464 | Pride
Bace1 interactome alzheimer 
ProteomicsBACE1 KO mouse CSF LC-MSMS - Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo
Analysis of murine cerebrospinal fluid (CSF) by quantitative mass spectrometry is challenging due to low CSF volume, low total protein concentration and the presence of highly abundant proteins such as albumin. We demonstrate that the CSF proteome of individual mice can be analyzed in a quantitative...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-12 | PXD001514 | Pride
Mouse csf Csf Label-free quantification 
ProteomicsSurface glycoproteome of BACE1-inhibited neurons
The cell surface proteome is dynamic and has fundamental roles in cell signaling. Many surface membrane proteins are proteolytically released into a cell’s secretome, where they can have additional functions in cell-cell-communication. Yet, it remains challenging to determine the surface proteome an...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-08 | PXD008619 | Pride
Bace1 Surface N-glycoproteome Murine neurons 
GenomicsPostnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation
Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation
PRJNA901474 | ENA
GenomicsTranscriptional modulation of BACE1 ameliorates amyloid pathology and cognitive deficits in Alzheimer’s models
Transcriptional modulation of BACE1 in amyloid pathology
PRJEB107683 | ENA
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067413 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067461 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsSecretome and lysate proteomics of primary murine neurons with inactive BACE1
The β-secretase BACE1 has become a prime target in Alzheimer’s disease (AD) therapy, because it drives the production of pathogenic amyloid β peptides. However, clinical trials with BACE1-targeting drugs were halted due to adverse effects on cognitive performance. We propose here that cognitive impa...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-10 | PXD065011 | Pride
Neurons Mouse Hispecs Bace1 Secretome 
GenomicsBACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
PRJNA957689 | ENA
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