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ProteomicsSecretomics of ADAM17 and iRhom2 KO BV2 cells using high-performance secretome protein enrichment with click sugars
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is unknown. Another microglia-expressed AD ri...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-10 | PXD054894 | Pride
Mouse Bv2 Hispecs Timstof pro Adam17 Diapasef Microglia Irhom2 Secretome Rhbdf2 
ProteomicsThe pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system
Proteolytic ectodomain shedding of membrane proteins is a fundamental mechanism to control the communication between cells and their environment. A key protease for membrane protein shedding is ADAM17, which requires a non-proteolytic subunit, either inactive Rhomboid 1 (iRhom1) or iRhom2 for its ac...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-07 | PXD028096 | Pride
Mouse Neuron Hispecs Csf 
ProteomicsProteomics of ADAM17 and iRhom2 KO microglia using high-performance secretome protein enrichment with click sugars
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is unknown. Another microglia-expressed AD ri...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-10 | PXD054898 | Pride
Mouse Hispecs Timstof pro Adam17 Diapasef Microglia Irhom2 Secretome Rhbdf2 
ProteomicsSecretome and lysate proteomics of primary murine neurons with inactive BACE1
The β-secretase BACE1 has become a prime target in Alzheimer’s disease (AD) therapy, because it drives the production of pathogenic amyloid β peptides. However, clinical trials with BACE1-targeting drugs were halted due to adverse effects on cognitive performance. We propose here that cognitive impa...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-10 | PXD065011 | Pride
Neurons Mouse Hispecs Bace1 Secretome 
ProteomicsSecretome profiling of iPSC-derived microglia from β-propeller protein-associated neurodegeneration patients
Microglia are the brain’s resident immune cells, essential for homeostasis and implicated in common neurodegenerative diseases like Alzheimer’s and Parkinson’s disease (PD), where their early activation and sustained inflammatory mediator release precede neuronal loss. By contrast, their contributio...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD071930 | Pride
Bpan Microglia Hispecs Secretome 
UnknownAn optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome.
Not available
S-EPMC7560198 | biostudies-literature
UnknownCab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning.
Not available
S-EPMC9825660 | biostudies-literature
ProteomicsSecretome Analysis of hippocampal and cortical murine neurons
To understand how cells communicate with each other, it is essential to define the cellular secretome, a collection of proteins including soluble secreted, unconventionally secreted and proteolytically-shed proteins. Quantitative methodologies to decipher the secretome are challenging, due to the re...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-25 | PXD020503 | Pride
Neurons Bace1 Secretome 
UnknownQuantitative proteomics establishes the cell type-resolved mouse brain secretome
Not available
S-SCDT-EMBOJ-2020-105693 | biostudies-other
UnknownThe pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.
Not available
S-EPMC8624807 | biostudies-literature
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