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TranscriptomicsConditional keratinocyte-specific ADAM17 knockout in mice alters skin homeostasis
This study investigates the role of ADAM17 (a disintegrin and metalloproteinase 17) in skin homeostasis. Here, we show that mice lacking ADAM17 in keratinocytes have a normal epidermal barrier and skin architecture at birth, but develop pronounced defects in epidermal barrier integrity soon after bi...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-38830 | biostudies-arrayexpress
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
We have demonstrated that site-directed mutagenesis in ADAM17 (ADAM17cytoF730A) also disrupts the interacting interface with Trx-1, resulting in a decrease of Trx-1 reductive capacity and activity. One of the mechanisms that explain this effect might be that ADAM17cyto favors Trx-1 monomerization st...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD015431 | Pride
Adam17 Thioredoxin-1 Mass spectrometry Redox signaling. Dimerization Iodotmt 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-15 | PXD055223 | Pride
Adam17 Ectodomain shedding Mouse Hepsec Secretome Metalloproteases 
ProteomicsAPP/PS1 Mouse Brain Effects of ADAM17
Affects of ADAM17 AAV9 mediated injection on cognitive and vascular function in the APP/PS1 mouse model of Alzheimer's disease.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD040026 | Pride
Brain App/ps1 Mouse Adam17 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17. Evaluation of heparin effects on sample preparation by FASP.
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-23 | PXD054987 | Pride
Sheddome Adam17 Ectodomain shedding Disintegrin metalloproteinases Secretome 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17 - Evaluation of heparin effects on sample preparation PreOmics
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055002 | Pride
Sheddome Adam17 Ectodomain shedding Heparin Disintegrin metalloproteinases Secretome 
GenomicsBlockade of the Protease ADAM17 Ameliorates Experimental Pancreatitis
Blockade of the Protease ADAM17 Ameliorates Experimental Pancreatitis
PRJNA886653 | ENA
ProteomicsADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways
Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is enabled by its remarkable capacity to systematically subvert host immune defences. In exploring the finding that HCMV infection upregulates tumor necrosis factor receptor 2 (TNFR2), a ligand for the proinflammatory...
ORGANISM(S): Cytomegalovirus Homo sapiens (Human) 
2023-10-11 | PXD044082 | Pride
Ul148 Tnfr2 Immune Adam17 Natural killer cell Human cytomegalovirus 
ProteomicsSecretomics of ADAM17 and iRhom2 KO BV2 cells using high-performance secretome protein enrichment with click sugars
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is unknown. Another microglia-expressed AD ri...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-10 | PXD054894 | Pride
Mouse Bv2 Hispecs Timstof pro Adam17 Diapasef Microglia Irhom2 Secretome Rhbdf2 
TranscriptomicsExpression data from Adam17 knock out mice and wild type
Adam17, a shedding protease, is strongly upregtulated during inflammation and cancer. Here we investigate the genome wide effects of Adam17 knock out on the transcriptome. Mouse tissue samples from n=3 wildtype colon, n=3 Adam17 knockout colon, n=3 wildtype skin and n=3 Adam17 knockout skin were use...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-21691 | biostudies-arrayexpress
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