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MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
ProteomicsStructural determinants of heparinâ??transforming growth factor-β1 interactions and their effects on signalling
Transforming growth factor-Ã?1 (TGF-Ã?1, Uniprot: P01137) is a heparin-binding protein that has been implicated in a number of physiological processes, including the initiation of chondrogenesis by human mesenchymal stem cells (hMSCs). Here, we identify the molecular features in the protein and in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079921 | MassIVE
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort1
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008467 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort2
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008468 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsHeparin-binding human plasma proteins
Identification of heparin-binding proteins from human blood plasma
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD055179 | Pride
Heparin Glycosaminoglycan 
ProteomicsHeparin-binding proteome in normal pancreas and murine experimental pancreatitis_C4PR_LIV
Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in cell communication. Therefore, we used heparin affinity proteomics to identify extracellula...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-17 | PXD012039 | Pride
Murine Pancreatitis Heparin-binding proteins (hbps) 
ProteomicsProteomics analysis of extracellular vesicles purified by heparin chromatography.
Extracellular vesicles (EVs) were isolated from U2OS cell (Human) conditioned medium (Input) was fractionated into two subpopulations named non-heparin binding (NHB) and heparin-binding (HB). Proteomics analysis was performed on Input, NHB and HB samples. The two main goals for this analysis are: fi...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD039845 | Pride
Extracellular vesicles Proteomics Heparin Lc-ms/ms 
ProteomicsStructural determinants of heparin–transforming growth factor-β1 interactions and their effects on signalling
Transforming growth factor-ß1 (TGF-ß1, Uniprot: P01137) is a heparin-binding protein that has been implicated in a number of physiological processes, including the initiation of chondrogenesis by human mesenchymal stem cells (hMSCs). Here, we identify the molecular features in the protein and in h...
ORGANISM(S): Homo sapiens (Human) 
2015-09-01 | PXD002772 | Pride
Transforming growth factor-β1 Heparan sulfate Heparin Proteoglycans 
ProteomicsThe heparin-binding proteome in nomal pancreas and murine experimental acute pancreatitis, C4PR_LIV
Acute pancreatitis (AP) is an acute inflammation of the pancreas, mainly caused by gallstones and alcohol, and driven by changes in communication between cells. Heparin-binding proteins (HBPs) of the plasma membrane and extracellular matrix play a central role in cell communication. Therefore, we us...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-11 | PXD001950 | Pride
Pancreas Mouse Lcmsms 
TranscriptomicsHeparin promotes cardiac differentiation of human pluripotent stem cells in chemically defined albumin-free medium enabling consistent manufacture of cardiomyocytes
Cardiomyocytes can be differentiated from human pluripotent stem cells (hPSCs) in defined conditions, but efficient and consistent cardiomyocyte differentiation often requires expensive reagents such as B27 supplement or recombinant albumin. Using a chemically defined albumin-free (E8 basal) medium,...
ORGANISM(S): Homo sapiens 
2016-07-28 | E-GEOD-81711 | biostudies-arrayexpress
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