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ProteomicsSuccessive protein extraction using hydroxylamine to increase the depth of proteome coverage in fresh, forensic and archaeological bones
Proteomics is continually being applied to a wider range of applications, now including the analysis of archaeological samples and anatomical specimens, in particular, collagen-containing tissues such as bones and teeth. Here we present the application of a chemi-cal digestion-based proteomics sampl...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-03-28 | PXD046969 | Pride
Hydroxylamine Collagen Archaeology Chemical digestion 
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort2
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008468 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort1
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008467 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsLabel free metaproteome examination of lyophilized fecal microbiota transplant (LFMT) and lyophilized sterile fecal filtrate (LSFF), and their effects on gut function during resolution of recurrent Clostridioides difficile infection (rCDI).
This project centers on the analysis of the human gut microbiota by 3 complementary technologies- bottom-up metaproteomics, chemical isotope labeled LC-MS metabolomics, and proximity ligation metagenomics. Stool samples were collected from 7 rCDI patients participated in a clinical trial which compa...
ORGANISM(S): Homo sapiens (Human) 
2026-09-23 | PXD072731 | Pride
ProteomicsQuantitative proteomics reveal that CB2R agonist JWH-133 downregulates NF-κB activation, oxidative stress, and lysosomal exocytosis from HIV-infected macrophages
HIV-associated neurocognitive disorders (HAND) affect 15-55% of HIV-positive patients, with no therapy. HIV-infected monocyte-derived macrophages (MDM) invade the brain of these individuals, promoting neurotoxicity. We demonstrated increased expression of cathepsin B (CATB), a lysosomal protease, in...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048464 | Pride
Proteomics Human Macrophages Neurotoxicity Oxidative stress Hiv Hand Cb2r Cathepsin b 
ProteomicsEvaluation of Ca37 monoclonal antibody against pathogenic fungal Candidozyma auris
Candidozyma auris, previously known as Candida auris, is a recently found pathogenic yeast that causes systemic infections, showing a high mortality rate. Moreover, this species is highly resistant to the commonly used antifungal drugs and some of the strains are multiresistant. This fungus is also ...
ORGANISM(S): [Candida] auris 
2026-01-05 | PXD070229 | Pride
Fungi Candidozyma auris Alcohol deshydrogenase Monoclonal antibody 
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