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TranscriptomicsPosterior Amorphous Corneal Dystrophy Is Associated with a Deletion of Small Leucine-rich Proteoglycans on Chromosome 12
Posterior amorphous corneal dystrophy (PACD) is a rare, autosomal dominant disorder affecting the cornea and iris. After next-generation sequencing of the family in which linkage analysis identified a chromosomal locus for PACD on 12q21.33 failed to yield a pathogenic mutation, array-based copy numb...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-50573 | biostudies-arrayexpress
ProteomicsN- and O-Glycoproteomic Analysis of Complex Proteoglycans
Proteoglycans are a small but diverse family of proteins that play a wide variety of roles at the cell surface and extracellular matrix. In addition to their glycosaminoglycan (GAG) chains, they are also N- and O-glycosylated. All of these types of glycosylation are crucial to their function, but pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-05-06 | PXD041935 | Pride
Proteoglycans Glycoproteomics Tandem mass spectrometry 
ProteomicsProteoglycan sequencing - Deep sequencing of complex proteoglycans: a novel strategy for high coverage and site-specific identification of glycosaminoglycan-linked peptides
Proteoglycans are distributed in all animal tissues and play critical, multifaceted, physiological roles. Expressed in a spatially- and temporally-regulated manner, these molecules regulate interactions among growth factors and cell surface receptors and play key roles in basement membranes and oth...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2018-05-22 | PXD008855 | Pride
Neurocan Decorin Lc-ms Aggrecan Brevican 
TranscriptomicsChemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle
Chemokines have been suggested to play a role during development of left ventricular failure, but little is known about their role during right ventricular (RV) remodeling and dysfunction. The first aim of this study was to identify chemokines which are regulated during RV pressure overload. We then...
ORGANISM(S): Mus musculus 
2011-08-09 | E-GEOD-30922 | biostudies-arrayexpress
UnknownGlycosaminoglycans and Proteoglycans.
Not available
S-EPMC5874723 | biostudies-literature
UnknownProteoglycans and catabolic products of proteoglycans present in ligament.
Not available
S-EPMC1134708 | biostudies-literature
UnknownProteoglycans in liver cancer.
Not available
S-EPMC4698501 | biostudies-literature
UnknownHeparan Sulfate Proteoglycans in Tauopathy.
Not available
S-EPMC9776397 | biostudies-literature
ProteomicsProximity labeling by a recombinant APEX2-FGF1 fusion protein reveals interaction of FGF1 with the proteoglycans CD44 and CSPG4
Fibroblast growth factor 1 (FGF1) binds to specific FGF receptors (FGFRs) at the surface of target cells to initiate intracellular signaling. In addition, FGF1 also binds to heparan sulfate proteoglycans (HSPG), which act as important co-receptors. Even if some interactions with HSPGs have been char...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009302 | Pride
Proteomics Proximity labeling Fgf1 
TranscriptomicsTo better understand the molecular basis for modulation of glycosaminoglycans (GAGs) and proteoglycans post-UV exposure
UV irradiation is a major environmental effector of skin damage and aging. Elevated levels of glycosaminoglycans (GAGs), as measured by Hale’s stain, are seen following cutaneous photodamage. Preliminary data from our lab indicates that this is a complex response involving differential regulation of...
ORGANISM(S): Homo sapiens 
2011-10-03 | GSE32552 | GEO
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