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Primary cardiac myocytes isolated from neonatal Wistar rats were cultured and simulated ischemia/reperfusion injury were conducted on them in the presence or absence of decorin. Decorin is a small leucin-rich proteoglycan, which has a cardiocytoprotective effect. The underlaying mechanism of this ca...
ORGANISM(S): Rattus norvegicus 
Decorin protects cardiac myocytes against simulated ischemia/reperfusion injury
Proteoglycans are distributed in all animal tissues and play critical, multifaceted, physiological roles. Expressed in a spatially- and temporally-regulated manner, these molecules regulate interactions among growth factors and cell surface receptors and play key roles in basement membranes and oth...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2018-05-22 | PXD008855 | Pride
Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such as the EGFR and Met. This leads to potent and sustained signal...
ORGANISM(S): Mus musculus 
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