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ProteomicsProximity labeling by a recombinant APEX2-FGF1 fusion protein reveals interaction of FGF1 with the proteoglycans CD44 and CSPG4
Fibroblast growth factor 1 (FGF1) binds to specific FGF receptors (FGFRs) at the surface of target cells to initiate intracellular signaling. In addition, FGF1 also binds to heparan sulfate proteoglycans (HSPG), which act as important co-receptors. Even if some interactions with HSPGs have been char...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009302 | Pride
Proteomics Proximity labeling Fgf1 
TranscriptomicsTranscriptome analysis of human astrocytes upon FGF1 stimulation
In a previous study performed in our laboratory, the level of FGF1 RNA was found to be increased in remyelinated multiple sclerosis lesions compared to control brain (unpublished observation). Astrocytes play a key role in multiple sclerosis lesion formation. To shed light on potential FGF1-mediated...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-MTAB-2485 | biostudies-arrayexpress
GenomicsRNA-seq analysis of MPCs treated with FGF1 variants
RNA-seq analysis of MPCs treated with FGF1 variants
PRJNA517177 | ENA
GenomicsRNA-seq analysis of diabetes treated with FGF1 variants
RNA-seq analysis of diabetes treated with FGF1 variants
PRJNA642731 | ENA
TranscriptomicsA PPAR?-FGF1 axis is required for adaptive adipose remodeling
We identify fibroblast growth factor 1 (FGF1) as a critical transducer in adipose tissue remodeling and link its regulation to peroxisome proliferator activated-receptor ? (PPAR?), the adipocyte master regulator and target of the thiazolidinedione (TZD) class of insulin sensitizing drugs. We show th...
ORGANISM(S): Mus musculus 
2012-04-22 | E-GEOD-31692 | biostudies-arrayexpress
OtherTargeted metabolomics of liver after FGF1 injection
We have performed measured levels of metabolites involved in gluconeogenesis in liver. Over-night fasted ob ob mice that were injected with vehicle or FGF1 for 2h were used for the analysis.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-11-11 | MSV000088351 | MassIVE
TranscriptomicsA PPARγ-FGF1 axis is required for adaptive adipose remodeling
We identify fibroblast growth factor 1 (FGF1) as a critical transducer in adipose tissue remodeling and link its regulation to peroxisome proliferator activated-receptor γ (PPARγ), the adipocyte master regulator and target of the thiazolidinedione (TZD) class of insulin sensitizing drugs. We show th...
ORGANISM(S): Mus musculus 
2012-04-23 | GSE31692 | GEO
UnknownFGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities.
Not available
S-EPMC4849156 | biostudies-literature
UnknownDirect binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
Not available
S-EPMC2440593 | biostudies-literature
GenomicsLiver Endothelial Zonation Orchestrates Hepatic Steatosis Onset through Retinoic Acid-regulated FGF1
Liver Endothelial Zonation Orchestrates Hepatic Steatosis Onset through Retinoic Acid-regulated FGF1
PRJNA1397179 | ENA
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