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TranscriptomicsTNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP
The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or intestinal bowel disease (IBD). Interestingly, XLP-2 patients display high levels of IL-18 in the serum even while in stable ...
ORGANISM(S): Mus musculus 
2021-03-01 | E-MTAB-10103 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of TNFR2-knockout mouse colon
PURPOSE: The goal of this study was to determine the gene expression networks regulated by tumor necrosis factor receptor 2 (TNFR2, or Tnfrsf1b) and to evaluate their potential bearing on immune cell subsets and inflammatory bowel disease (IBD). METHODS: mRNA-seq was performed on isolated distal col...
ORGANISM(S): Mus musculus 
2015-08-11 | E-GEOD-65408 | biostudies-arrayexpress
ProteomicsTreg cells from human blood differentiate into non-lymphoid tissue-resident effector cells upon TNFR2 costimulation
Regulatory T (Treg) cells can facilitate transplant tolerance and attenuate autoimmune- and inflammatory diseases. Therefore, it is clinically relevant to stimulate Treg cell expansion and function in vivo and to create therapeutic Treg cell products in vitro. We report that TNF receptor 2 (TNFR2) i...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD048248 | Pride
Human Ttreg Tconv Tnfr2 Conventional t cell Cd28 Thymus-derived regulatory t cell Treg Regulatory t cell Costimulation 
TranscriptomicsSingle-cell immune repertoire sequencing of bone marrow and splenic B cells following TNFR2 immunizations
We performed single-cell transcriptome and antibody repertoire sequencing of bone marrow and splenic B cells from mice of different age following protein (TNFR2) immunizations
ORGANISM(S): Mus musculus 
2023-08-02 | E-MTAB-12610 | biostudies-arrayexpress
TranscriptomicsExpression data from TNF-stimulated mouse glomeruli
The specific contribution of the two TNF-receptors Tnfr1 and Tnfr2 to TNF-induced inflammation in the glomerulus is unknown. In mice, TNF exposure induces glomerular expression of inflammatory mediators like adhesion molecules and chemokines in vivo, and glomerular accumulation of leukocytes. To exa...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-43928 | biostudies-arrayexpress
GenomicsExpression data of human Tregs treated with TNFR2 agonist antibody
Expression data of human Tregs treated with TNFR2 agonist antibody
PRJNA767809 | ENA
GenomicsTNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation
TNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation
PRJNA801247 | ENA
GenomicsSingle-cell RNA-seq data of human Tregs treated with TNFR2 agonist antibody
Single-cell RNA-seq data of human Tregs treated with TNFR2 agonist antibody
PRJNA767808 | ENA
GenomicsTNFR2 signaling regulates the immunomodulatory function of oligodendrocyte precursor cells
TNFR2 signaling regulates the immunomodulatory function of oligodendrocyte precursor cells
PRJNA748767 | ENA
TranscriptomicsSingle-cell immune repertoire sequencing of bone marrow plasma cells following infection and immunizations
We performed single-cell transcriptome and antibody repertoire sequencing of bone marrow plasma cells following protein (OVA and TNFR2) immunizations or infection with high dose LCMV clone 13.
ORGANISM(S): Mus musculus 
2021-12-01 | E-MTAB-11096 | biostudies-arrayexpress
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