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TranscriptomicsmiRNA expression in CD4+CD25- conventional (Tconv) and CD4+CD25+ regulatory T (Treg) cells
miRNA expression profiling in highly purified murine CD4+ Tconv and Treg cells. FoxP3-GFP-hCre1a(high) reporter mice were used to separate both populations based on surface markers and presence or absence of GFP. Two-condition experiment, Tconv vs. Treg. Biological replicates: 1 Tconv, 1 Treg, purif...
ORGANISM(S): Mus musculus 
2013-06-06 | E-GEOD-30847 | biostudies-arrayexpress
TranscriptomicsDetection of differentially methylated regions in CD4+CD25+CD45RA+ regulatory T-cells and conventional CD4+CD25- T-cells
We have previously developed an approach that fractionates genomic DNA fragments depending on their CpG density (methyl-CpG-immunoprecipitation, MCIp), and adapted this approach to identify regions that are differentially methylated in the two closely related regulatory T-cells (Treg cells) and conv...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-14233 | biostudies-arrayexpress
TranscriptomicsHistone H3 Lysine 4 mono-, di- and trimethyl and CTCF in CD4+CD25+CD45RA+ regulatory and conventional CD4+CD25- T-cells
Analysis of Histone H3 Lysine 4 mono-, di- and trimethyl and the boundary protein CTCF in CD4+CD25+CD45RA+ regulatory T-cells and conventional CD4+CD25- T-cells. To investigate regulatory functions or potential new transcription start sites in Treg and Tconv cells, we investigated the associated hi...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14234 | biostudies-arrayexpress
TranscriptomicsHuman IFNG+/- Treg and Tconv transcriptome
Microarray used to detail the global gene transcription underlying sorted IFNg+ and IFNg- Tregs (CD4+CD25+CD127lo) and Tconv (CD4+CD25-CD127+) for fresh (unexpanded) and 14 day expanded cells from human blood. Treg and Tconv were FACS isolated from five healthy subjects (median age of 26, range 22-3...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-59786 | biostudies-arrayexpress
TranscriptomicsGene expression profile of conventional T cells (Tconv) and regulatory T cells (Treg) stimulated with anti-costimulatory molecule antibodies
Co-stimulatory molecules of the CD28 family on T lymphocytes integrate cues from innate immune system sensors, and modulate activation responses in conventional CD4+ T cells (Tconv) and their FoxP3+ regulatory counterparts (Treg). To better understand how costimulatory and co-inhibitory signals migh...
ORGANISM(S): Mus musculus 
2012-11-15 | E-GEOD-42276 | biostudies-arrayexpress
ProteomicsProteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells
The CD4+ regulatory T (Treg) cell lineage comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. As a model for Treg cells, studies employ TGF-β-induced (i)Treg cells generated from CD4+ conventional T (Tconv) cells in vitro. Here, we describe the relationship of iTreg cells ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-28 | PXD038302 | Pride
Human Ttreg Tconv Itreg Conventional t cell Thymus-derived regulatory t cell Induced regulatory t cell Treg Tgf-beta Regulatory t cell 
GenomicsTconv and Treg gene expression and repertoire analysis of WT mice
Tconv and Treg gene expression and repertoire analysis of WT mice
PRJNA746269 | ENA
GenomicsGenome-wide measuement of methylated cytosin in regulatory T cells (Treg) and conventional T cells (Tconv) depleted with Uhrf1
To investigate the molecular mechanism how Uhrf1 regulate gene expression and cell cycle progression in Treg, we precipitated methylated DNA using recombinant MBD1 followed by genome-wide analysis of methylated gene loci by next generation sequencer Examination of methylated DNA in Treg and Tconv i...
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-56543 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of freshly sorted and expanded regulatory and conventional T cells
Transcriptome analysis of freshly sorted regulatory T cells (CD4+CD25+) and conventional T cells (CD4+CD25-) and of expansion cultures of regulatory T cells (CD4+CD25+CD45RA+) and conventional T cells (CD4+CD25-). Three biological replicates were performed of freshly sorted Treg and Tconv cells each...
ORGANISM(S): Homo sapiens 
2009-05-20 | E-GEOD-14232 | biostudies-arrayexpress
UnknownCD161+ Tconv and CD161+ Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire.
Not available
S-EPMC5337494 | biostudies-literature
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