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UnknownCapacity of tTreg generation is not impaired in the atrophied thymus.
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S-EPMC5695848 | biostudies-literature
GenomicsVAT CD4+ T cell responses in the absence of either tTreg or pTreg cells
VAT CD4+ T cell responses in the absence of either tTreg or pTreg cells
PRJNA1265633 | ENA
ProteomicsProteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells
The CD4+ regulatory T (Treg) cell lineage comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. As a model for Treg cells, studies employ TGF-β-induced (i)Treg cells generated from CD4+ conventional T (Tconv) cells in vitro. Here, we describe the relationship of iTreg cells ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-28 | PXD038302 | Pride
Human Ttreg Tconv Itreg Conventional t cell Thymus-derived regulatory t cell Induced regulatory t cell Treg Tgf-beta Regulatory t cell 
TranscriptomicsRNA-seq analysis of transcriptomes of thymus derived tTreg cells and the exFoxp3 precursor cells
To determine the phenotype of the precursor of exFoxp3 cells and find the signals that affect the stability of tTreg cells, we analysis the transcriptomes of epigenetic stable thymus derived tTreg cells and the exFoxp3 precursor cells.
ORGANISM(S): Mus musculus 
2017-03-01 | GSE93856 | GEO
TranscriptomicsVAT CD4+ T cell responses in the absence of either tTreg or pTreg cells
Foxp3⁺ regulatory T (Treg) cells are important regulators in maintenance of visceral adipose tissue (VAT) homeostasis. The relative contributions of thymus-derived (tTreg) and peripherally induced (pTreg) subsets to the VAT Treg pool have remained unclear due to the absence of definitive lineage mar...
ORGANISM(S): Mus musculus 
2026-09-13 | GSE297656 | GEO
ProteomicsTreg cells from human blood differentiate into non-lymphoid tissue-resident effector cells upon TNFR2 costimulation
Regulatory T (Treg) cells can facilitate transplant tolerance and attenuate autoimmune- and inflammatory diseases. Therefore, it is clinically relevant to stimulate Treg cell expansion and function in vivo and to create therapeutic Treg cell products in vitro. We report that TNF receptor 2 (TNFR2) i...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD048248 | Pride
Human Ttreg Tconv Tnfr2 Conventional t cell Cd28 Thymus-derived regulatory t cell Treg Regulatory t cell Costimulation 
TranscriptomicsImmune Gene Expression Profile of Conventional and Regulatory T cells
Understanding human regulatory T cells (Tregs) heterogeneity may identify markers of disease pathogenesis and facilitate the development of optimized cellular therapeutics. To better elucidate human Treg subsets, we conducted direct transcriptional profiling of CD4+FOXP3+Helios+ thymic-derived Treg ...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-GEOD-61834 | biostudies-arrayexpress
GenomicsMus musculus
RNA-seq analysis of transcriptomes of thymus derived tTreg cells and the exFoxp3 precursor cells
PRJNA362608 | ENA
OtherAlpha/Beta Mouse TCR Sequencing of CD4+ thymic regulatory and conventional T-cells
Thymic regulatory T cells (tTreg) are critical in maintenance of normal T cell immunity and tolerance. The role of TCR in tTreg cell selection remains incompletely understood. Here we assessed TCRa and TCRb sequences of tTreg and conventional thymic CD4+ T (Tconv) cells by high throughput sequencing...
ORGANISM(S): Mus musculus 
2020-01-10 | GSE143291 | GEO
TranscriptomicsComparison of human CD39- and CD39+ thymus-derived regulatory T-cells
CD39- and CD39+ human thymus-derived regulatory T-cells (tTreg) present as distinct subsets with specific functional and metabolic response patterns. Both cell types express equal levels of the canonical tTreg transcription factors FOXP3 and Helios and overexpression studies have shown that CD39 exp...
ORGANISM(S): Homo sapiens 
2020-07-02 | GSE131743 | GEO
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