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MetabolomicsUntargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages with or without LPS and ATP costimulation
Untargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages without stimulation or with 4 hours of LPS preconditioning and subsequently 30 min of ATP stimulation.
2025-07-08 | MTBLS12152 | MetaboLights
ProteomicsTreg cells from human blood differentiate into non-lymphoid tissue-resident effector cells upon TNFR2 costimulation
Regulatory T (Treg) cells can facilitate transplant tolerance and attenuate autoimmune- and inflammatory diseases. Therefore, it is clinically relevant to stimulate Treg cell expansion and function in vivo and to create therapeutic Treg cell products in vitro. We report that TNF receptor 2 (TNFR2) i...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD048248 | Pride
Human Ttreg Tconv Tnfr2 Conventional t cell Cd28 Thymus-derived regulatory t cell Treg Regulatory t cell Costimulation 
ProteomicsInteractomics of the RLTPR protein explain its essential role for costimulation via CD28
The RLTPR cytosolic protein has an essential role in CD28 costimulation but its mode of action and importance in human T cells remain elusive. Here, using mass spectrometry we showed that CD28, RLTPR and the CARMA1 cytosolic adaptor physically associate in mouse T cells. Although RLTPR is thought to...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD003870 | Pride
Mouse Rltpr Lc-ms/ms 
GenomicsDetermine anti-Siglec-F and IL-33 costimulation induced transcriptional changes on murine eosinophils
Determine anti-Siglec-F and IL-33 costimulation induced transcriptional changes on murine eosinophils
PRJNA702493 | ENA
UnknownCostimulation Blockade in Kidney Transplant Recipients.
Not available
S-EPMC6978297 | biostudies-literature
GenomicsMyeloid Niches Sustain Antitumor T Cells and License PD-1 Blockade via CD28 Costimulation
Myeloid Niches Sustain Antitumor T Cells and License PD-1 Blockade via CD28 Costimulation
PRJNA738136 | ENA
UnknownPredicting clinical response to costimulation blockade in autoimmunity.
Not available
S-EPMC7613378 | biostudies-literature
TranscriptomicsDetermine anti-Siglec-F and IL-33 costimulation induced transcriptional changes on murine eosinophils
Eosinophils costimulation with anti-Siglec-F and IL-33 synergistically increases their IL-4 and IL-13 release (Willebrand et al. PLoS One 2016). Here we analyze costimulation induced transcriptional changes involved that potentially enhance effector release.
ORGANISM(S): Mus musculus 
2021-11-23 | GSE166968 | GEO
UnknownCostimulation blockade and Tregs in solid organ transplantation.
Not available
S-EPMC9478950 | biostudies-literature
TranscriptomicsEffect of costimulation on microRNAs levels in human naïve CD4 T cells
microRNA transcriptional profiling of human naïve CD4 T cells comparing cells that saw no activation, only anti-CD3 or anti-CD3 and anti-CD28 to identify microRNAs specifically upregulated by CD28-mediated costimulation. Three conditions experiment. PBS, anti-CD3, anti-CD3 + anti-CD28 all compared t...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-36071 | biostudies-arrayexpress
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