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TranscriptomicsEffect of ibuprofen on hippocampal gene expression in APP-PS1 mice
NSAIDs (non-steroidal anti-inflammatory drugs) inhibit cyclooxygenase (COX) enzymes and prevent Alzheimer'™s disease (AD) at preclinical stages in cognitively normal aging populations. We modeled NSAID prevention of memory impairment in AD model mice to identify novel targets of NSAID action. We fou...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-67306 | biostudies-arrayexpress
ProteomicsAPP/PS1 Mouse Brain Effects of ADAM17
Affects of ADAM17 AAV9 mediated injection on cognitive and vascular function in the APP/PS1 mouse model of Alzheimer's disease.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD040026 | Pride
Brain App/ps1 Mouse Adam17 
TranscriptomicsMicroRNA expression profiles in WT and APP/PS1 mouse hippocampus
With the criterion of 2-fold cutoff, 7 miRNAs were upregulated and 7 miRNAs were downregulated in APP/PS1 hippocampal tissues compared with WT hippocampal tissues Microarray analysis of miRNAs was performed on pooled hippocampal tissues from WT (n=16) and APP/PS1 mice (n=16) at E14
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-53859 | biostudies-arrayexpress
TranscriptomicsAPP/PS1 mice characterization and time progression.
RNA samples from the cerebral cortex of APP/PS1 and WT mouse littermates aged 3, 6 and 12 months were analyzed using the Affymetrix Genechip Mouse Gene 1.1 ST Array. The APP-PS1 transgenic mouse express the human mutated forms APPswe and PS1dE9. This is a good model of familial Alzheimer Disease bec...
ORGANISM(S): Mus musculus 
2014-04-30 | E-MTAB-2121 | biostudies-arrayexpress
TranscriptomicsRNA-seq of hippocampal samples from IL-18KO/APP/PS1 , WT, IL-18KO, and APP/PS1 mice.
The goal of the experiment was to understand the role of IL-18 in Alzheimers disease. Gene expression was examined in the hippocampus of wild type mice and the APP/PS1 mice (which are a mouse model for Alzheimers disease) that either encoded IL-18 or had the IL-18 gene knocked out.
ORGANISM(S): Mus musculus domesticus 
2017-12-31 | E-MTAB-5668 | biostudies-arrayexpress
ProteomicsProteome profiling in APP/PS1 mice brain and modulation by tocotrienol-rich fraction
This study examined the proteome profile in the hippocampus, medial prefrontal cortex, and striatum of APPswe/PS1dE9 transgenic mice (APP/PS1) model of Alzheimer’s disease compared to wild-type mice. The effect of tocotrienol-rich fraction (TRF), a mixture of vitamin E analogs derived from palm oil ...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-06 | PXD011068 | Pride
App/ps1 mice Alzheimer’s disease Brain Vitamin e Tocotrienol-rich fraction 
ProteomicsAge-dependent hippocampal proteomics in the APP/PS1 Alzheimer mouse model: a comparative analysis with classical SWATH/DIA and directDIA approaches
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the human population, for which there is currently no cure. The cause of AD is unknown, however, the toxic effects of amyloid-β (Aβ) are believed to play a role in its onset. To investigate this, we examined changes in global ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-24 | PXD025777 | Pride
Proteomics Alzheimer Microglia App/ps1 mouse model Directdia Ms-dap 
TranscriptomicsSingle cell sequencing of astrocytes in the APP NL-F and APP PS1 models of ß-amyloidopathy
Bulk RNA-sequencing of astrocytes in the APP NL-F and APP PS1 models of ß-amyloidopathy, in which aspects of AD-related pathology progress at different speed, shows age-dependent gene expression changes. However, bulk RNA-seq does not provide insight into the heterogeneity of expression within this ...
ORGANISM(S): Mus musculus 
2024-03-21 | E-MTAB-13937 | biostudies-arrayexpress
ProteomicsBrain proteomics in APP/PS1 mice
(Phospho)proteomic analysis of brain material derive from APP/PS1 vs wild type littermates (15 days-old)
ORGANISM(S): Mus Musculus (mouse) 
2024-10-16 | PXD046158 | JPOST Repository
GenomicsTranscriptomic analysis of microglia from young and aged wild-type, NLRP3-/-, APP/PS1 and APP/PS1.NLRP3-/- mice.
Transcriptomic analysis of microglia from young and aged wild-type, NLRP3-/-, APP/PS1 and APP/PS1.NLRP3-/- mice.
PRJNA1124066 | ENA
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