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ProteomicsMS-DAP platform for label-free proteomics uncovers optimal workflows in benchmark datasets and increased sensitivity in analysis of Alzheimer's biomarker data
In the rapidly moving proteomics field, a diverse patchwork of algorithms for data normalization and differential expression analysis is used by the community. We generated an all-inclusive mass spectrometry downstream analysis pipeline (MS-DAP) that integrates many algorithms for normalization and ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-03-10 | PXD036134 | Pride
Alzheimer’s disease Proteomics Software Benchmarking Bioinformatics 
UnknownMS-DAP Platform for Downstream Data Analysis of Label-Free Proteomics Uncovers Optimal Workflows in Benchmark Data Sets and Increased Sensitivity in Analysis of Alzheimer's Biomarker Data.
Not available
S-EPMC9903323 | biostudies-literature
ProteomicsAge-dependent hippocampal proteomics in the APP/PS1 Alzheimer mouse model: a comparative analysis with classical SWATH/DIA and directDIA approaches
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the human population, for which there is currently no cure. The cause of AD is unknown, however, the toxic effects of amyloid-β (Aβ) are believed to play a role in its onset. To investigate this, we examined changes in global ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-24 | PXD025777 | Pride
Proteomics Alzheimer Microglia App/ps1 mouse model Directdia Ms-dap 
ProteomicsPodophyllum hexandrum Royle MS/MS
In order to study the molecular mechanisms of cold-adaption and PPT accumulation to understand why P. hexandrum adapts to chilling temperature, the differentially expressed proteins (DAPs) of P. hexandrum seedling exposed to chilling temperatures (4 and 10°C, 22°C as control) were conducted by usin...
ORGANISM(S): Sinopodophyllum hexandrum 
2017-05-15 | PXD003334 | Pride
Podophyllum hexandrum royle Chilling temperature Growth and development Gene expression Proteomics Podophyllotoxin biosynthesis 
ProteomicsProteomes of dissected developing barley endosperm layers and microscopy identifies the starchy endosperm as prominent tissue for the storage of ER derived hordeins accompanied by the accumulation of HvPDIL1-1 and its intracellular re-localization
Barley (Hordeum vulgare) is one of the major food sources for humans and forage source for animal livestock. Barley endosperm is structured into three distinct cell layers: the starchy endosperm, which acts essentially as storage tissue for starch, the subaleurone, which is characterized by a high a...
ORGANISM(S): Hordeum vulgare (Barley) 
2018-10-01 | PXD009710 | Pride
Hvpdil 1-1 Barley caryopsis Shotgun proteomics Hordeins Endoplasmic reticulum Laser microdissection 
UnknownAminopyridines for the treatment of neurologic disorders.
Not available
S-EPMC5310209 | biostudies-literature
UnknownRapid LC-MS/MS quantification of Organophosphate non-specific metabolites in hair using alkaline extraction approach.
Not available
S-EPMC10474783 | biostudies-literature
UnknownMicroscopic and Proteomic Analysis of Dissected Developing Barley Endosperm Layers Reveals the Starchy Endosperm as Prominent Storage Tissue for ER-Derived Hordeins Alongside the Accumulation of Barley Protein Disulfide Isomerase (HvPDIL1-1).
Not available
S-EPMC6139375 | biostudies-literature
UnknownStudy on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis.
Not available
S-EPMC6742383 | biostudies-literature
UnknownInteraction of Phenyl-Substituted Diazaperylenium with Cucurbit[n]uril: Complex versus Supramolecular Polymer.
Not available
S-EPMC7081634 | biostudies-literature
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