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TranscriptomicsEarly Induction of NRF-2 Antioxidant Pathway by RHBDF2 Mediates More Rapid Cutaneous Healing in Mice
Rhomboid family protein RHBDF2, an upstream regulator of the epidermal growth factor (EGF) receptor signaling, has been implicated in cutaneous wound healing. However, the underlying molecular mechanisms are still emerging. Using a gain-of-function mutation in the mouse Rhbdf2 gene (Rhbdf2cub/cub), ...
ORGANISM(S): Mus musculus 
2017-06-01 | GSE95250 | GEO
UnknownRHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome.
Not available
S-EPMC3276661 | biostudies-literature
UnknownRHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression.
Not available
S-EPMC8567583 | biostudies-literature
UnknownEarly induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.
Not available
S-EPMC5436942 | biostudies-literature
UnknownRHBDF2 governs microglial neuroinflammation during cerebral ischemia-reperfusion injury and is positively regulated by the m6A reader YTHDF1.
Not available
S-EPMC12403488 | biostudies-literature
UnknownStructural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.
Not available
S-EPMC5358332 | biostudies-literature
UnknownA genome-wide association study in mice reveals a role for Rhbdf2 in skeletal homeostasis.
Not available
S-EPMC7039944 | biostudies-literature
TranscriptomicsRHBDF2 in Stromal Fibroblasts Mediates TGF-b Signal and Enhances Cancer Cell Invasion via Intercellular Cross-Talk
Cancer-associated fibroblasts (CAFs) existing in tumor stroma play a crucial role in tumor progression. Here, we show that stromal fibroblasts near cancer cells are likely to display up-regulated RHBDF2 expression caused by chronic stimulation from pro-inflammatory cytokines. RHBDF2 promotes both th...
ORGANISM(S): Homo sapiens 
2018-08-21 | GSE83834 | GEO
UnknownThe E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes.
Not available
S-EPMC8881609 | biostudies-literature
UnknownInvestigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer.
Not available
S-EPMC9703992 | biostudies-literature
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