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MetabolomicsPhosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the role...
2021-09-28 | MTBLS3485 | MetaboLights
TranscriptomicsA transcriptome-wide atlas of RNP compositions reveals diverse classes of mRNAs and lncRNAs
Aim: To determine how different classes of transcript (e.g. lncRNAs and mRNAs) are defined in the cell. Approach: We determined the transcriptome-wide targets of key RNA packaging, maturation, export and turnover factors. We used the CRAC technique, whereby RNA:protein interactions are fixed by UV ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-08-29 | E-GEOD-46742 | biostudies-arrayexpress
MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis seedling treated with norflurazon-induced photobleaching of chloroplasts
Regulation of expression of genes encoding chloroplast components is critical to the autotrophic plant and never more so than in the cotyledons of the de-etiolating seedling. Many chloroplast proteins are nuclear-encoded and a retrograde signal from the chloroplasts (the Plastid Signal) modulates nu...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5726 | biostudies-arrayexpress
MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis seedling response to norflurazon-induced photobleaching of chloroplasts
Regulation of expression of genes encoding chloroplast components is critical to the autotrophic plant and never more so than in the cotyledons of the de-etiolating seedling. Many chloroplast proteins are nuclear-encoded and a retrograde signal from the chloroplasts (the Plastid Signal) modulates nu...
ORGANISM(S): Arabidopsis thaliana 
2022-11-21 | E-NASC-40 | biostudies-arrayexpress
GenomicsGenome-wide nucleosome position data for 3 yeast species
Genome-wide nucleosome position data for wildtype and mutant strains in S. cerevisiae, C. albicans, and S. pombe Illumina sequencing of mononucleosomal DNA isolated from mid-log cultures grown in rich medium (abbreviated CM, in house recipe). S. pombe samples were grown in YES medium at permissive t...
ORGANISM(S): Candida albicans 
2011-08-01 | E-GEOD-28839 | biostudies-arrayexpress
TranscriptomicsTo compare the levels of expression of the different glycosyltransferases in order to explain the exclusive detection of LeX in the neurons
Human NT2- cells differentiate in vitro into NT2N neurons in the presence of retinoic acid, and culture in the presence of mitosis inhibitors. We have previously observed the presence of the Lewisx determinant exclusively in NT2N neurons but not in NT2- cells. We also obtained evidence that Lex is s...
ORGANISM(S): Homo sapiens 
2011-10-02 | E-GEOD-32554 | biostudies-arrayexpress
TranscriptomicsTo study the relationship between 5-HT7 gene expressions and the expression of the glycan binding protein NCAM
Adult Neurogenesis and Gene Expression Changes in 5-HT7 Receptor Knockout Mice: In the adult, the formation of new nerve cells in the CNS is restricted to the subependymal layer and to the subgranular zone of the hippocampus (Duman et al., 2001). Clinically adult neurogenesis has received most atten...
ORGANISM(S): Mus musculus 
2011-09-05 | E-GEOD-31924 | biostudies-arrayexpress
TranscriptomicsContinue study of the roles of galectins in parasitic infection
Our laboratory previously reported that galectins may act as parasite recognizing molecules (Leishmania) (JBC 277:17663 and JBC 278:22223). Now we are studying the role of galectin-3 in leishmaniasis in vivo, using G3KO mice. Thus, we analyzed RNA from leuckotyes of draining lymph nodes of both KO ...
ORGANISM(S): Mus musculus 
2011-09-05 | E-GEOD-31925 | biostudies-arrayexpress
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