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ProteomicsMining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in numerous essential cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homology challenging. This ...
ORGANISM(S): Staphylococcus aureus 
2018-10-17 | PXD006483 | Pride
Pyridoxal phosphate Cofactor Vitamin b6 
ProteomicsIntramembrane client recognition potentiates the chaperone functions of calnexin
One-third of the human proteome is comprised of membrane proteins, which are particularly vulnerable to misfolding and often require folding assistance by molecular chaperones. Calnexin (CNX), which engages client proteins via its sugar-binding lectin domain, is one of the most abundant ER chaperone...
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD031140 | Pride
Membrane proteins Protein quality control Molecular chaperones Calnexin 
ProteomicsA comprehensive set of ER PDI family members supports the biogenesis of pro-inflammatory interleukin 12 family cytokines
Cytokines of the interleukin 12 (IL-12) family are assembled combinatorially from shared alpha and beta subunits. A common theme is that human IL-12 family alpha subunits remain incompletely structured in isolation until they pair with a designate beta subunit. Accordingly, chaperones need to suppor...
ORGANISM(S): Homo sapiens (Human) 
2022-11-28 | PXD036463 | Pride
Interleukin Chaperone Protein disulfide isomerase Protein folding Genetic code expansion 
ProteomicsInactivity of peptidase ClpP causes primary accumulation of mitochondrial disaggregase ClpX with its interactors at the nucleoid and RNA granule
Mitochondrial matrix peptidase ClpP inactivating mutations in human cause an autosomal recessive Perrault syndrome variant (PRLTS3), characterized by ovarian failure with early sensorineural deafness, often followed by general neurodegeneration. Mouse models showed that accumulations of (i) its main...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD029418 | Pride
Lars2  twnk  eral1  clpb Leukodystrophy  ataxia  parkinson’s disease  hars2 
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