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Metabolomicsengineered bacillus subtilis protect the weaned piglets from ETEC K88 infection
engineered bacillus subtilis protect the weaned piglets from ETEC K88 infection through improving serum metabolites, intestinal imcrobiota, antioxidant and immune activity.
2026-02-23 | MTBLS7587 | MetaboLights
Metabolomics2E,4E-decadienoic acid, a novel anti-oomycete agent from co-culture of Bacillus subtilis and Trichoderma asperellum

Phytophthora nicotianae is an oomycete pathogen of global significance threatening many important crops. It is mainly controlled by chemosynthetic fungicides, which endangers ecosystem and human health; thus, there is an urgent need to explore alternatives for these fungicides. In this s...

2022-08-01 | MTBLS5405 | MetaboLights
MetabolomicsReducing the use of chemical fertilizers and improving crop salt stress tolerance by acetoin and 2,3-butanediol produced by Bacillus subtilis

Small volatile molecules are considered to play a role in promoting plant growth, with acetoin and 2,3-butanediol being representative examples. In this study, we employed metabolic engineering of Bacillus subtilis to enhance the production of acetoin and 2,3-butanediol, and investigated the...

2025-10-16 | MTBLS13110 | MetaboLights
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
TranscriptomicsCell envelope metabolism in phosphate limited Bacillus subtilis cells
Investigation of the whole genome expression level changes in phosphate limited Bacillus subtilis wild-type and delta-phoPR cells Investigation of the whole genome expression level changes of wild-type and delta-phoPR Bacills subtilis cells comparing high and low phosphate medium For each sample ana...
ORGANISM(S): Bacillus subtilis 
2011-07-12 | E-GEOD-23164 | biostudies-arrayexpress
MetabolomicsEngineered Bacillus subtilis WB600/ZD reduces post-weaning diarrhea in piglets by modulating gut microbiota and aryl hydrocarbon receptor (AHR) signaling

Post-weaning diarrhea (PWD) causes significant economic losses to the pig farming industry. Our previous study demonstrated that the engineered Bacillus subtilis WB600/ZD (an engineered Bacillus subtilis strain expressing the antimicrobial defensin peptide from Zophobas atratus), alleviates intes...

2025-08-15 | MTBLS12862 | MetaboLights
TranscriptomicsBenzoate induced transcriptomic response in Bacillus subtilis
Bacillus subtilis strain AG174 was grown in the presence and absence of benzoate (30 mM). Benzoate was used in order to equalize the external and internal pH. The cultures were grown at external pH 7.0, and the addition of benzoate did not change the external pH. Microarray analysis was performed o...
ORGANISM(S): Bacillus subtilis 
2010-05-19 | E-GEOD-12263 | biostudies-arrayexpress
TranscriptomicsProbing the regulatory effects of specific mutations in three major binding domains of the pleiotropic regulator CcpA of Bacillus subtilis
Study the effect of single amino acid point mutations in CcpA at the transcriptome level. Cells were grown in LB with or without 1% glucose and harvested at an OD600 of 0.3 (early exponential phase). Bacillus subtilis strain ccpA::spec carrying pHT304 (empty plasmid), pWH_ccpA_M17R, pWH_ccpA_T62H, o...
ORGANISM(S): Bacillus subtilis 
2015-12-24 | E-GEOD-69575 | biostudies-arrayexpress
TranscriptomicsThe regulon of the pleiotropic transcription factor Spx in Bacillus subtilis
The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of Bacillus subtilis cells exposed to disulfide stress. Defects in Spx were previously shown to lead to differential expression of numerous genes but direct and indirect regulatory effects could not be distinguis...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2012-09-06 | E-GEOD-35097 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in spo0J mutant and wild-type B. subtilis
We investigated the genome-wide DNA binding of the chromosome partitioning and sporulation protein and ParB family member Spo0J in Bacillus subtilis using chromatin immunoprecipitation and DNA microarrays. We identified ten parS loci to which Spo0J binds, two of which were unexpectedly distant (>1 ...
ORGANISM(S): Bacillus subtilis 
2010-06-11 | E-GEOD-6598 | biostudies-arrayexpress
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