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We have studied the regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells (ESCs) and neuronal progenitors. We find that both complexes influence transcription by binding to promoters as well as TSS-distal enhancer regions. In contrast to flies, the MSL co...
ORGANISM(S): Mus musculus 
The airm of the approach was to identify genes in whole Xenopus tadpoles (Stage NF42) that are upregulated or downregulated due to disruption of the fkbp4 by CRISPR-Cas9 gene editing compared to control tadpoles. Xenopus fkbp4 crispants were generated to make a model of a novel human syndrome caused...
ORGANISM(S): Xenopus tropicalis 
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