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MetabolomicsPaternal microbiome perturbations impact offspring fitness

The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, t...

2024-02-12 | MTBLS1629 | MetaboLights
MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
MetabolomicsArgR-dependent Bacterial Resistance to Host Lipid Droplets in Edwardsiella piscicida
Lipid droplets (LDs), as innate immune hubs, function in the front line of antimicrobial defense involved in the ongoing host-pathogen arms race. Particularly for intracellular bacterial pathogens, the endowed capacity to resist host LDs can effectively facilitate pathogen in vivo colonization and e...
2025-07-04 | MTBLS9590 | MetaboLights
ProteomicsMassively parallel fitness profiling reveals multiple novel enzymes in Pseudomonas putida lysine metabolism
The lysine metabolism of Pseudomonas putida can produce multiple important commodity chemicals and is implicated in rhizosphere colonization. However, despite intensive study, the biochemical and genetic links between lysine metabolism and central metabolism remains unresolved in P. putida. Here, we...
ORGANISM(S): Pseudomonas Putida Kt2440 
2019-05-17 | PXD011350 | panorama
TranscriptomicsComparison of salt stress resistance genes in transgenic Arabidopsis thaliana indicates that extent of transcriptomic change may not predict secondary phenotypic or fitness effects
Engineered abiotic stress resistance is an important target for increasing agricultural productivity.There are concerns, however, regarding possible ecological impacts of transgenic crops. In contrast to the first wave of transgenic crops, many abiotic stress resistance genes can initiate complex do...
ORGANISM(S): Arabidopsis thaliana 
2011-10-05 | E-GEOD-26983 | biostudies-arrayexpress
ProteomicsIn vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut
Sulfonamides are traditional synthetic antimicrobial agents used in clinical and veterinary medical settings. Their long-term excessive overuse has resulted in widespread microbial resistance, limiting their application for medical interventions. Resistance to sulfonamides is primarily conferred by ...
ORGANISM(S): Escherichia Coli Str. K-12 Substr. Mg1655 
PXD053633 |
TranscriptomicsTranscription profiling of Salmonella enterica serotype SL1344 wildtype, pSf-R27sfh and pSf-R27 at stationary and exponential growth phases, to investigate the role of the Sfh protein encoded by transmissible plasmids and involved in human typhoid
The Sfh protein is encoded by self-transmissible plasmids involved in human typhoid and is closely related to the global regulator H-NS. We have found that Sfh provides a stealth function that allows the plasmids to be transmitted to new bacterial hosts with minimal effects on their fitness. Introdu...
ORGANISM(S): Salmonella enterica serotype Typhimurium 
2007-01-15 | E-SGRP-7 | biostudies-arrayexpress
ProteomicsStaphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase
The transition from growth to stationary phase is a natural response of bacteria to starvation and stress. When stress is alleviated and more favorable growth conditions return, bacteria resume proliferation without a significant loss in fitness. Although specific adaptations that enhance the persis...
ORGANISM(S): Staphylococcus aureus 
2022-05-19 | PXD029457 | Pride
Clpx Soda Stationary phase Clpp Competitive fitness Staphylococcus aureus Cell death 
TranscriptomicsGlycan effect on Saccharolytic Human Distal Gut Symbiont, B. thetaiotaomicron
This SuperSeries is composed of the following subset Series: GSE11944: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont GSE11953: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont: ECF ...
ORGANISM(S): Bacteroides thetaiotaomicron 
2008-11-20 | E-GEOD-11980 | biostudies-arrayexpress
GenomicsBacterial Fitness Landscapes Stratify Based on Proteome Allocation Associated with Discrete Aero-types
Bacterial Fitness Landscapes Stratify Based on Proteome Allocation Associated with Discrete Aero-types
PRJNA689602 | ENA
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