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ProteomicsCerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children
Clinically distinguishing acute bacterial meningitis from cerebral malaria, both of which are important causes of acute non-traumatic coma associated with morbidity and mortality among paediatric hospital admissions in malaria endemic areas of Africa, is challenging. Few hospitals have diagnostic ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-24 | MSV000080979 | MassIVE
TranscriptomicsTranscription profiling of rat hippocampus and cortex in the time series of Pneumococcal Meningitis infection
The aim of this work is to describe the transcriptomic changes underlying the complex mechanisms of the host response to pneumococcal meningitis in a temporal and spatial context. For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain da...
ORGANISM(S): Rattus norvegicus 
2010-02-24 | E-MEXP-1656 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat cerebral cortex and hippocampus from animals with pneumococcal meningitis treated with dexamethasone
Effect of adjuvant dexamethasone treatment on gene expression in the hippocampus and cortex of control rats or rats suffering from pneumococcal meningitis which were sacrificed 72 h after infection.
ORGANISM(S): Rattus norvegicus 
2011-02-28 | E-MEXP-2953 | biostudies-arrayexpress
TranscriptomicsPeripheral blood RNA gene expression profiling in patients with bacterial meningitis
The aim of present study was to describe the genetic pathways activated during the community acquired bacterial meningitis (BM) by using genome-wide RNA expression profiling combined with functional annotation of transcriptional changes. We included 21 patients with BM hospitalized in 2008. The cont...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-40586 | biostudies-arrayexpress
TranscriptomicsInflammasome-dependent Interferon-gamma drives pathogenesis in Streptococcus pneumoniae meningitis.
A comparison of brain gene expression profiles in wildtype mice and interferon gamma -/- mice during bacterial meningitis.
ORGANISM(S): Mus musculus 
2012-09-01 | E-MEXP-3697 | biostudies-arrayexpress
TranscriptomicsVitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcript...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-MEXP-3555 | biostudies-arrayexpress
GenomicsHost genotyping data from Dutch adult bacterial meningitis patients and linked bacterial genome sequences
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. This st...
EGAS00001005993 | EGA
TranscriptomicsTranscription profiling by array of pneumococcal virulence factors expressed during meningitis in mice
Streptococcus pneumoniae is the most common cause of severe bacterial meningitis in children, the elderly, and immunocompromised individuals. To identify virulence factors preferentially expressed during meningitis, we conducted niche-specific genome-wide in vivo transcriptomic analysis after intran...
ORGANISM(S): Streptococcus pneumoniae 
2012-04-10 | E-BUGS-130 | biostudies-arrayexpress
ProteomicsValue of lipocalin 2 as a potential biomarker for bacterial meningitis
Objectives: Central nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly and accurately identify the likely cause of the infections, essential for clinical management and improving outcome. Methods: We app...
ORGANISM(S): Homo sapiens (Human) 
2020-08-20 | PXD020510 | Pride
Cns Csf Bacterial meningitis 
ProteomicsCSF quantitative proteomics reveals potential diagnostic biomarker of pediatric bacterial meningitis
In this study, we performed label-free based CSF quantitative proteomics to identify and analyze the differentially expressed proteins among bacterial meningitis, viral meningitis and hospital controls (children with benign intracranial hypertension). Compared with viral meningitis and hospital cont...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD026663 | Pride
Csf Bacterial meningitis Diagnostic biomarker 
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