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MetabolomicsResource Partitioning of Diatom Metabolites that Support Bacterial Heterotrophy in the Ocean (NMR assay)

The communities of marine bacteria that assemble around living microphytoplankton are predictably dominated by three taxonomic groups, each of which specializes in the use or transport of different components of the available metabolite pool: Rhodobacterales transport small and polar metabolites,...

2020-09-15 | MTBLS1544 | MetaboLights
MetabolomicsThe Cd-tolerance of pepper (Capsicum annuum L.) is linked with rhizosphere bacterial community composition and rhizosphere soil metabolites profiles

Cadmium (Cd) poses a serious threat to plant growth, so the selection and breeding of Cd-tolerant pepper cultivars is an effective method to reduce Cd hazards. This study identified C. annuum G03 as a Cd-tolerant cultivar, evidenced by its superior leaf physiological activity under Cd stress comp...

2025-10-23 | MTBLS13200 | MetaboLights
MetabolomicsResource Partitioning of Diatom Metabolites that Support Bacterial Heterotrophy in the Ocean (UPLC-MS assay)

The communities of marine bacteria that assemble around living microphytoplankton are predictably dominated by three taxonomic groups, each of which specializes in different components of the available metabolite pool: Rhodobacterales transport small and polar metabolites, Flavobacteriia use carb...

2020-09-15 | MTBLS1751 | MetaboLights
MetabolomicsCoral symbiotic bacterial community and metabolites changes under thermal stress: A case of laboratory experiment with heating treatment
Coral bleaching and coral reef degradation become severe as the surface seawater temperature rises. Much research to date has focused on the bacterial community composition properties within the coral holobiont, but less attention has been paid to the interactions of bacteria and corals under therma...
2022-10-27 | MTBLS5272 | MetaboLights
MetabolomicsMetabolomic analysis of extracellular metabolites from bacterial strains SL8, SL12 and their co-culture under cadmium stress

In this study, bacterial strains 'SL8', 'SL12', and the cocultured 'SL8+SL12' were cultivated in LB medium with or without 100 mg/L cadmium(II) for 48 hours (six replicates per treatment). After centrifugation, extracellular metabolites in the supernatant were extracted using a methanol acetonitr...

2026-05-26 | MTBLS14477 | MetaboLights
MetabolomicsUntargeted metabolomics links glutathione to bacterial cell cycle progression
Cell cycle progression requires the coordination of cell growth, chromosome replication, and division. Consequently, a functional cell cycle must be coupled with metabolism. However, direct measurements of metabolome dynamics remained scarce, in particular in bacteria. Here, we describe an untargete...
2020-10-15 | MTBLS1402 | MetaboLights
MetabolomicsExometabolomic profiling of bacterial strains cultivated using Arabidopsis root extract as the sole carbon source
The ability of microorganisms to use root-derived metabolites as growth substrates is a key trait for success in the rhizospheric niche. However, few studies describe which specific metabolites are consumed, or to what degree microbial strains differ in their substrate consumption patterns. Here we ...
2018-10-16 | MTBLS555 | MetaboLights
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
MetabolomicsSystematic identification of bacterial factors driving Staphylococcus aureus intracellular lifestyle in non-professional phagocytes

Staphylococcus aureus is a major human pathogen responsible for severe infections. While traditionally described as extracellular, increasing evidence establishes S. aureus as a facultative intracellular pathogen. Intracellularity contributes to immune evasion, dissemination, and antibiotic failu...

2025-10-26 | MTBLS13220 | MetaboLights
MetabolomicsA synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance

The lack of new drugs that are effective against antibiotic-resistant bacteria has caused increasing concern in global public health. Based on this study, we report development of a modified antimicrobial drug through structure-based drug design (SBDD) and modular synthesis. The optimal modified ...

2024-07-03 | MTBLS10516 | MetaboLights
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