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ProteomicsStructures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation
The 26S proteasome primarily degrades proteins marked by polyubiquitin chains. Although ubiquitin-independent pathways for proteasomal degradation exist, the mechanisms involved remain poorly understood. Bag1 links Hsp70 chaperone to the 26S proteasome, recruiting Hsp70-bound aberrant proteins for d...
ORGANISM(S): Homo sapiens (Human) 
2025-01-27 | PXD058407 | Pride
Chaperones Degradation Hsp70 Bag1 Proteasome 
ProteomicsStructures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism for direct transfer of substrates to the catalytic chamber
Coupling of the degradation and chaperone systems, particularly under cellular stress, is essential for eliminating unfolded proteins. The co-chaperone Bag1 links the Hsp70 chaperone to the 26S proteasome, recruiting Hsp70-bound unfolded proteins for proteasomal degradation. Here, we present cryo-EM...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2025-12-23 | PXD069071 | Pride
Chaperones Degradation Hsp70 Bag1 Proteasome 
GenomicsA small molecule BAG1 inhibitor as therapeutic agent for androgen receptor positive prostate cancer
A small molecule BAG1 inhibitor as therapeutic agent for androgen receptor positive prostate cancer
PRJNA755637 | ENA
UnknownBAG1 down-regulation increases chemo-sensitivity of acute lymphoblastic leukaemia cells.
Not available
S-EPMC8435410 | biostudies-literature
UnknownInteraction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity.
Not available
S-EPMC1084317 | biostudies-literature
TranscriptomicsA small molecule BAG1 inhibitor as therapeutic agent for androgen receptor positive prostate cancer
BAG1 is a family of polypeptides with a conserved C-terminal BAG domain that functions as a nucleotide exchange factor for the molecular chaperone HSP70. BAG1 proteins also bind to diverse cellular proteins and control several signaling processes including proteostasis, apoptosis and transcription. ...
ORGANISM(S): Homo sapiens 
2022-05-05 | GSE182278 | GEO
UnknownBAG1: the guardian of anti-apoptotic proteins in acute myeloid leukemia.
Not available
S-EPMC3189928 | biostudies-literature
UnknownBag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Not available
S-EPMC1361767 | biostudies-literature
UnknownExpression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics.
Not available
S-EPMC7881605 | biostudies-literature
UnknownBAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments.
Not available
S-EPMC2430919 | biostudies-literature
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